2. Cell Cycle/DNA Damage Apoptosis
  3. APC Apoptosis
  4. CDC20-IN-2

CDC20-IN-2 (14c), a Cdc20 inhibitor (KD: 7.65 μM), causes G2/M phase arrest, promotes DNA damage accumulation, and stabilizes key substrates such as Cyclin B1 and Bim, leading to enhanced apoptosis and suppression of tumor cell proliferation and migration.

For research use only. We do not sell to patients.

CDC20-IN-2 Chemical Structure

CDC20-IN-2 Chemical Structure

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CDC20-IN-2 Related Antibodies

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Description

CDC20-IN-2 (14c), a Cdc20 inhibitor (KD: 7.65 μM), causes G2/M phase arrest, promotes DNA damage accumulation, and stabilizes key substrates such as Cyclin B1 and Bim, leading to enhanced apoptosis and suppression of tumor cell proliferation and migration[1].

In Vitro

CDC20-IN-2 (14c) exhibits IC50 values of 3.28 μM and 23.86 μM in MDA-MB-231 and MCF 10A cells, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CDC20-IN-2 Related Antibodies
Molecular Weight

701.26

Formula

C21H15Cl4F6N7O3S
SMILES

FC(F)(F)C1=CC=C(NC2=CC(Cl)=NC(NC(NC(OCCNC(C3=CN=C(C(F)(F)F)S3)=O)=O)C(Cl)(Cl)Cl)=N2)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CDC20-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDC20-IN-2APCApoptosisAnaphase promoting complexMDA-MB-231TNBCInhibitorinhibitorinhibit

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CDC20-IN-2
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HY-172401
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