Celivarone  (Synonyms: SSR149744C)

Celivarone (SSR149744C) is a orally active noniodinated benzofuran derivative with antiarrhythmic properties. Celivarone has the potential for atrial fibrillation and in ventricular arrhythmias research^[1].

Celivarone (SSR149744C) exhibits electrophysiological and hemodynamic properties of class I, II, III, and IV antiarrhythmic agents^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In vagally induced atrial fibrillation (AF) in anesthetized dogs, Celivarone (SSR149744C) (3 and 10 mg/kg IV) terminates AF in all 7 dogs and prevented reinduction in 4 out of 7 dogs^[2].
At the ventricular level, Celivarone (0.1-10 mg/kg IV and 3-90 mg/kg PO) prevents reperfusion-induced arrhythmias in anesthetized rats with a dose-effect relationship, and, at doses of 30 to 90 mg/kg PO, it reduced early (0-24 hours) mortality following permanent left coronary artery ligature in conscious rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

533.74

C₃₄H₄₇NO₄

401925-43-7

O=C(C1=CC2=C(OC(CCCC)=C2C(C3=CC=C(CCCN(CCCC)CCCC)C=C3)=O)C=C1)OC(C)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Avinash R Khitri, et al. Celivarone for maintenance of sinus rhythm and conversion of atrial fibrillation/flutter. J Cardiovasc Electrophysiol. 2012 May;23(5):462-72.  [Content Brief]

  [2]. Patrick Gautier, et al. In vivo and in vitro antiarrhythmic effects of SSR149744C in animal models of atrial fibrillation and ventricular arrhythmias. J Cardiovasc Pharmacol. 2005 Feb;45(2):125-35.  [Content Brief]