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Celivarone (SSR149744C) is a orally active noniodinated benzofuran derivative with antiarrhythmic properties. Celivarone has the potential for atrial fibrillation and in ventricular arrhythmias research.

For research use only. We do not sell to patients.

Celivarone Chemical Structure

Celivarone Chemical Structure

CAS No. : 401925-43-7

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Description

Celivarone (SSR149744C) is a orally active noniodinated benzofuran derivative with antiarrhythmic properties. Celivarone has the potential for atrial fibrillation and in ventricular arrhythmias research[1].

In Vitro

Celivarone (SSR149744C) exhibits electrophysiological and hemodynamic properties of class I, II, III, and IV antiarrhythmic agents[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In vagally induced atrial fibrillation (AF) in anesthetized dogs, Celivarone (SSR149744C) (3 and 10 mg/kg IV) terminates AF in all 7 dogs and prevented reinduction in 4 out of 7 dogs[2].
At the ventricular level, Celivarone (0.1-10 mg/kg IV and 3-90 mg/kg PO) prevents reperfusion-induced arrhythmias in anesthetized rats with a dose-effect relationship, and, at doses of 30 to 90 mg/kg PO, it reduced early (0-24 hours) mortality following permanent left coronary artery ligature in conscious rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

533.74

Formula

C34H47NO4

CAS No.
SMILES

O=C(C1=CC2=C(OC(CCCC)=C2C(C3=CC=C(CCCN(CCCC)CCCC)C=C3)=O)C=C1)OC(C)C

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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References
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Celivarone Related Classifications

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Celivarone
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HY-106207
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