2. Cell Cycle/DNA Damage PI3K/Akt/mTOR
  3. ATM/ATR
  4. Ceralasertib formate

Ceralasertib formate  (Synonyms: AZD-6738 formate)

Cat. No.: HY-123502
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Ceralasertib formate is a potent, selective and orally active ATR inhibitor with an IC50 value of 1 nM. Ceralasertib formate inhibits cell viability and induces DNA damage. Ceralasertib formate induces cell senescence. Ceralasertib formate shows antitumor activity.

For research use only. We do not sell to patients.

Ceralasertib formate Chemical Structure

Ceralasertib formate Chemical Structure

CAS No. : 1352280-98-8

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Ceralasertib formate Related Antibodies

Top Publications Citing Use of Products

36 Publications Citing Use of MCE Ceralasertib formate

WB

    Ceralasertib formate purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2022 Nov 16;41(1):323.  [Abstract]

    Ceralasertib (AZD6738; 1, 2 µM) signifcantly decreases the protein levels of ATR, IFI16 and HuR in a dose-dependent manner in GSC 267 and GSC 20 cells.

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    Description

    Ceralasertib formate is a potent, selective and orally active ATR inhibitor with an IC50 value of 1 nM. Ceralasertib formate inhibits cell viability and induces DNA damage. Ceralasertib formate induces cell senescence. Ceralasertib formate shows antitumor activity[1][2].

    In Vitro

    Ceralasertib formate (0, 0.3, 1 μM; 48 h) induces cell senescence in A549 cells in a dose-dependent manner[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Ceralasertib formate Related Antibodies
    Molecular Weight

    458.53

    Formula

    C20H24N6O2S.xCH2O2
    CAS No.
    SMILES

    C[C@H]1N(CCOC1)C2=CC(C3(CC3)[S@@](=N)(C)=O)=NC(C4=C5C(NC=C5)=NC=C4)=N2.OC=O.[F,Cl,Br,I]
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    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Ceralasertib formate Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Ceralasertib formate1352280-98-8AZD-6738 formateATM/ATRAtaxia telangiectasia mutatedATM and RAD3 relatedorally activeDNA damagesenescenceantitumorNSCLCA549 cellsInhibitorinhibitorinhibit

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