Ceralasertib formate (Synonyms: AZD-6738 formate)

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Ceralasertib formate is a potent, selective and orally active ATR inhibitor with an IC₅₀ value of 1 nM. Ceralasertib formate inhibits cell viability and induces DNA damage. Ceralasertib formate induces cell senescence. Ceralasertib formate shows antitumor activity.

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Ceralasertib formate Chemical Structure

CAS No. : 1352280-98-8

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37 Publications Citing Use of MCE Ceralasertib formate

: Ceralasertib formate purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2022 Nov 16;41(1):323. [Abstract]; Ceralasertib (AZD6738; 1, 2 µM) signifcantly decreases the protein levels of ATR, IFI16 and HuR in a dose-dependent manner in GSC 267 and GSC 20 cells.

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Description	Ceralasertib formate is a potent, selective and orally active ATR inhibitor with an IC₅₀ value of 1 nM. Ceralasertib formate inhibits cell viability and induces DNA damage. Ceralasertib formate induces cell senescence. Ceralasertib formate shows antitumor activity^[1]^[2].
In Vitro	Ceralasertib formate (0, 0.3, 1 μM; 48 h) induces cell senescence in A549 cells in a dose-dependent manner^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Ceralasertib formate Related Antibodies
Molecular Weight	458.53
Formula	C₂₀H₂₄N₆O₂S.xCH₂O₂
CAS No.	1352280-98-8
SMILES	C[C@H]1N(CCOC1)C2=CC(C3(CC3)[S@@](=N)(C)=O)=NC(C4=C5C(NC=C5)=NC=C4)=N2.OC=O.[F,Cl,Br,I]
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (277 KB) Handling Instructions (2659 KB)
References	[1]. Vendetti FP, et al. The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo. Oncotarget. 2015 Dec 29;6(42):44289-305. [Content Brief] [2]. Kim HJ, et al. Anti-tumor activity of the ATR inhibitor AZD6738 in HER2 positive breast cancer cells. Int J Cancer. 2017 Jan 1;140(1):109-119. [Content Brief]

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ceralasertib formate1352280-98-8AZD-6738 formateATM/ATRAtaxia telangiectasia mutatedATM and RAD3 relatedorally activeDNA damagesenescenceantitumorNSCLCA549 cellsInhibitorinhibitorinhibit

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