CFI-400936

Cat. No.: HY-123675: FAQs
Data Sheet Handling Instructions Technical Support

CFI-400936 is a potent TTK inhibitor with an IC₅₀ of 3.6 nM. CFI-400936 has antitumor activity.

For research use only. We do not sell to patients.

CFI-400936 Chemical Structure

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Description

CFI-400936 is a potent TTK inhibitor with an IC₅₀ of 3.6 nM. CFI-400936 has antitumor activity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	GI₅₀	0.16 μM Compound: 72, CFI-400936	Growth inhibition of human A549 cells after 5 days by SRB assay Growth inhibition of human A549 cells after 5 days by SRB assay	[PMID: 25043312]
HCT-116	GI₅₀	0.1 μM Compound: 72, CFI-400936	Growth inhibition of human HCT116 cells after 5 days by SRB assay Growth inhibition of human HCT116 cells after 5 days by SRB assay	[PMID: 25043312]
HCT-116	EC₅₀	0.52 μM Compound: 72, CFI-400936	Inhibition of TTK in human HCT116 cells assessed as phosphorylation of histone H3 at Ser10 residue after 4 hrs by immunoassay Inhibition of TTK in human HCT116 cells assessed as phosphorylation of histone H3 at Ser10 residue after 4 hrs by immunoassay	[PMID: 25043312]
MDA-MB-468	GI₅₀	0.66 μM Compound: 72, CFI-400936	Growth inhibition of human MDA-MB-468 cells after 5 days by SRB assay Growth inhibition of human MDA-MB-468 cells after 5 days by SRB assay	[PMID: 25043312]

Molecular Weight

477.58

Formula

C₂₅H₂₇N₅O₃S

CAS No.

1338793-07-9

SMILES

O=C(C(N(C)C)C1=C(CC)C=CC=C1)NC2=CC3=C(NN=C3C4=CC(S(=O)(N)=O)=CC=C4)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Laufer R, et al. Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides. Bioorg Med Chem. 2014 Sep 1;22(17):4968-97. [Content Brief]

CFI-400936 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CFI-4009361338793-07-9CFI400936CFI 400936Mps1Monopolar spindle 1TTKInhibitorantitumorinhibitorinhibit

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CFI-400936

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CFI-400936 Related Classifications

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