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CFM-1 is a small molecule antagonist of CARP-1/APC-2 binding with an EC50 value of 4.1 μM. CFM-1 induces G2M cell cycle arrest and suppresses viabilities of human breast cancer cells.

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CFM-1 Chemical Structure

CFM-1 Chemical Structure

CAS No. : 1380448-60-1

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CFM-1 Related Antibodies

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Description

CFM-1 is a small molecule antagonist of CARP-1/APC-2 binding with an EC50 value of 4.1 μM. CFM-1 induces G2M cell cycle arrest and suppresses viabilities of human breast cancer cells[1].

Cellular Effect
Cell Line Type Value Description References
Daoy IC50
8.12 μg/mL
Compound: CFM-1
Cytotoxicity against human DaOY cells assessed as inhibition of cell survival after 24 hrs by MTT assay
Cytotoxicity against human DaOY cells assessed as inhibition of cell survival after 24 hrs by MTT assay
[PMID: 25555142]
HeLa IC50
13.5 μg/mL
Compound: CFM-1
Cytotoxicity against human HeLa cells assessed as inhibition of cell survival after 24 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as inhibition of cell survival after 24 hrs by MTT assay
[PMID: 25555142]
Huh-7 IC50
8.18 μg/mL
Compound: CFM-1
Cytotoxicity against human HuH7 cells assessed as inhibition of cell survival after 24 hrs by MTT assay
Cytotoxicity against human HuH7 cells assessed as inhibition of cell survival after 24 hrs by MTT assay
[PMID: 25555142]
MDA-MB-231 IC50
19.7 μg/mL
Compound: CFM-1
Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell survival after 24 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell survival after 24 hrs by MTT assay
[PMID: 25555142]
Molecular Weight

355.23

Formula

C12H7BrN2O2S2
CAS No.
SMILES

O=C1NC2=C(C=C(Br)C=C2C)/C1=C(SC(N3)=S)\C3=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CFM-1 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CFM-11380448-60-1CFM1CFM 1OthersCARP-1/APC-2 bindingcell cycle arresthuman breast cancer cellsInhibitorinhibitorinhibit

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CFM-1
Cat. No.:
HY-116473
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