1. Metabolic Enzyme/Protease
  2. MMP
  3. CGS 27023A

CGS 27023A is a non-peptidic and orally active MMP inhibitor with the Ki values of 43, 33, 20 and 8 nM for MMP-3, MMP-1, MMP-2 amd MMP-9, respectively. CGS 27023A can be used for study of arthritis.

For research use only. We do not sell to patients.

CGS 27023A Chemical Structure

CGS 27023A Chemical Structure

CAS No. : 169799-04-6

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Description

CGS 27023A is a non-peptidic and orally active MMP inhibitor with the Ki values of 43, 33, 20 and 8 nM for MMP-3, MMP-1, MMP-2 amd MMP-9, respectively. CGS 27023A can be used for study of arthritis[1].

IC50 & Target

stromelysins 1

43 nM (Ki)

collagenases 1

33 nM (Ki)

MMP-2

20 nM (Ki)

MMP-9

8 nM (Ki)

Cellular Effect
Cell Line Type Value Description References
MCF7 IC50
3000 nM
Compound: 1, CGS-27023A
Inhibition of ADAM17 in human MCF7 cells assessed as inhibition of EGF-induced sALCAM release by ELISA
Inhibition of ADAM17 in human MCF7 cells assessed as inhibition of EGF-induced sALCAM release by ELISA
[PMID: 20180536]
MCF7 IC50
6900 nM
Compound: 1, CGS-27023A
Inhibition of ADAM17 in human MCF7 cells assessed as inhibition of constitutive sALCAM release by ELISA
Inhibition of ADAM17 in human MCF7 cells assessed as inhibition of constitutive sALCAM release by ELISA
[PMID: 20180536]
MCF7 IC50
750 nM
Compound: 1, CGS-27023A
Inhibition of ADAM17 in human MCF7 cells assessed as inhibition of pervanadate-induced sALCAM release by ELISA
Inhibition of ADAM17 in human MCF7 cells assessed as inhibition of pervanadate-induced sALCAM release by ELISA
[PMID: 20180536]
MDA-MB-468 IC50
10000 nM
Compound: 1, CGS-27023A
Inhibition of ADAM17 in human MDA-MB-468 cells assessed as inhibition of pervanadate-induced sALCAM release by ELISA
Inhibition of ADAM17 in human MDA-MB-468 cells assessed as inhibition of pervanadate-induced sALCAM release by ELISA
[PMID: 20180536]
MDA-MB-468 IC50
1400 nM
Compound: 1, CGS-27023A
Inhibition of ADAM17 in human MDA-MB-468 cells assessed as inhibition of constitutive sALCAM release by ELISA
Inhibition of ADAM17 in human MDA-MB-468 cells assessed as inhibition of constitutive sALCAM release by ELISA
[PMID: 20180536]
MDA-MB-468 IC50
750 nM
Compound: 1, CGS-27023A
Inhibition of ADAM17 in human MDA-MB-468 cells assessed as inhibition of EGF-induced sALCAM release by ELISA
Inhibition of ADAM17 in human MDA-MB-468 cells assessed as inhibition of EGF-induced sALCAM release by ELISA
[PMID: 20180536]
SK-OV-3 IC50
110 nM
Compound: 1, CGS-27023A
Inhibition of ADAM17 in human SKOV3 cells assessed as inhibition of EGF-induced sALCAM release by ELISA
Inhibition of ADAM17 in human SKOV3 cells assessed as inhibition of EGF-induced sALCAM release by ELISA
[PMID: 20180536]
SK-OV-3 IC50
13000 nM
Compound: 1, CGS-27023A
Inhibition of ADAM17 in human SKOV3 cells assessed as inhibition of constitutive sALCAM release by ELISA
Inhibition of ADAM17 in human SKOV3 cells assessed as inhibition of constitutive sALCAM release by ELISA
[PMID: 20180536]
In Vivo

CGS 27023A (oral gavage, 75 µmol/kg for 10 h) prevents cartilage degradation in stromelysin-induced rabbit cartilage degradation model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

429.92

Formula

C18H24ClN3O5S

CAS No.
SMILES

CC(C)[C@@H](N(S(=O)(C1=CC=C(OC)C=C1)=O)CC2=CC=CN=C2)C(NO)=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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CGS 27023A Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
CGS 27023A
Cat. No.:
HY-18694
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