Chitinase, Serratia marcescens  (Synonyms: AMCase, Serratia marcescens)

Chitinase, Serratia marcescens (EC 3.2.1.14) has partial lysozyme activity and is widely found in bacteria, fungi, animals and some plants. Chitinase belongs to the glycosyl hydrolase family. Chitinase catalyzes chito-oligosaccharide hydrolysis. Chitinases also can serve as prognostic biomarkers of disease progression. Chitinase can be used in the research of pathogenesis of various human fibrotic and inflammatory disorders, particularly those of the lung (idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease, sarcoidosis, and asthma) and the gastrointestinal tract (inflammatory bowel diseases (IBDs) and colon cancer)^[1][2].

Instructions
Soluble in 50 mM potassium phosphate, pH 6.0 (1 mg/mL), this product contains a protective agent.
*Reported in the literature A stock solution of this product is prepared in 118 mM NaCl, 48 mM KCl, 2 mM CaCl₂, 2 mM MgCl₂ and 25 mM HEPES buffer (pH 7.3, concentration 2 mg/mL), and aliquots of this stock solution can be stored at –20 °C for several months.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

9001-06-3

Solid

Light yellow to light brown

[Chitinase, serratia marcescens]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Iseli B, et al. Plant chitinases use two different hydrolytic mechanisms. FEBS Lett. 1996 Mar 11;382(1-2):186-8.  [Content Brief]

  [2]. Mazur M, et al. Chitinases and Chitinase-Like Proteins as Therapeutic Targets in Inflammatory Diseases, with a Special Focus on Inflammatory Bowel Diseases. Int J Mol Sci. 2021 Jun 28;22(13):6966.  [Content Brief]