2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC Apoptosis
  4. Chlamydocin

Chlamydocin, a fungal metabolite, is a highly potent HDAC inhibitor, with an IC50 of 1.3 nM. Chlamydocin exhibits potent antiproliferative and anticancer activities. Chlamydocin induces apoptosis by activating caspase-3.

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Chlamydocin Chemical Structure

Chlamydocin Chemical Structure

CAS No. : 53342-16-8

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Chlamydocin Related Antibodies

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

Chlamydocin, a fungal metabolite, is a highly potent HDAC inhibitor, with an IC50 of 1.3 nM. Chlamydocin exhibits potent antiproliferative and anticancer activities. Chlamydocin induces apoptosis by activating caspase-3[1].

IC50 & Target[1]

HDAC

1.3 nM (IC50)

In Vitro

Chlamydocin is originally isolated from the fungus Diheterospora chlamydosporia. Chlamydocin exhibits a broad spectrum of antiproliferative activity toward various cancer cell lines, irrespective of their p53 status. The antiproliferative activity of Chlamydocin is accompanied by accumulation of hyperacetylated histones H3 and H4, induction of p21cip1/waf1, and accumulation of cells in G2/M phase of the cell cycle[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chlamydocin Related Antibodies
Molecular Weight

526.62

Formula

C28H38N4O6
CAS No.
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References
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Chlamydocin Related Classifications

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Keywords:

Chlamydocin53342-16-8HDACApoptosisHistone deacetylasescyclictetrapeptidaccumulationhyperacetylatedhistonesH3H4A2780ovariancancercellsInhibitorinhibitorinhibit

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