Chlorfortunone A

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Chlorfortunone A is a novel sesquiterpenoid dimers, can be isolated from the roots of Chloranthus fortunei. Chlorfortunone A inhibits transforming growth factor (TGF)-β activity.

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Chlorfortunone A Chemical Structure

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Description

Chlorfortunone A is a novel sesquiterpenoid dimers, can be isolated from the roots of Chloranthus fortunei. Chlorfortunone A inhibits transforming growth factor (TGF)-β activity^[1].

In Vitro

Chlorfortunone A (compound 1) (10-40 μM; 4 h) downregulates TGF-β-induced Smad2 phosphorylation (A) and the expression of vimentin (B) in MDA-MB-231 cells^[1].
Chlorfortunone A (25 μM; 48 h) significantly downregulated the expression of vimentin, a Smad-regulated EMT-marker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	MDA-MB-231 cells
Concentration:	10, 20, 40 μM
Incubation Time:	4 hours; accompanied with 10 ng/mL TGF-β1 for 30 min
Result:	Significantly downregulated the TGF-β-induced p-Smad2 expression in a concentration-dependent manner without any impact on the expression of Smad2/3 protein.

Immunofluorescence^[1]

Cell Line:	MDA-MB-231 cells
Concentration:	25 μM
Incubation Time:	48 hours
Result:	Significantly downregulated the expression of vimentin.

Molecular Weight

490.63

Formula

C₃₁H₃₈O₅

SMILES

C[C@@]1([C@@H]2C[C@@H]2C(CC3)=C1[C@]([C@]3(C=C4)C=C[C@@]4([C@@H](C(C)C)C5)[C@@H](C5=O)C)([H])/C6=C(C)/C(OC)=O)[C@@H](O)C6=O

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wu xujia, et al. Chlorfortunones A and B, Two Sesquiterpenoid Dimers, Possessing Dispiro[4,2,5,2]pentadecane-6,10,14-tren Moiety from Chloranthus fortunei. ACS Omega 2022.