2. Metabolic Enzyme/Protease Apoptosis
  3. NAMPT Apoptosis
  4. CHS-828 (nicotinate)

CHS-828 (nicotinate)  (Synonyms: GMX1778 (nicotinate))

Cat. No.: HY-10079A
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CHS-828 nicotinate is a competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), with an IC50 less than 25 nM. CHS-828 nicotinate (GMX1778) exerts a cytotoxic effect by decreasing the cellular level of NAD+ and exhibits a potent anticancer activity.

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CHS-828 (nicotinate) Chemical Structure

CHS-828 (nicotinate) Chemical Structure

CAS No. : 1160589-73-0

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CHS-828 (nicotinate) Related Antibodies

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Description

CHS-828 nicotinate is a competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), with an IC50 less than 25 nM. CHS-828 nicotinate (GMX1778) exerts a cytotoxic effect by decreasing the cellular level of NAD+ and exhibits a potent anticancer activity[1].

Molecular Weight

494.97

Formula

C25H27ClN6O3
CAS No.
SMILES

N#CN/C(NCCCCCCOC1=CC=C(C=C1)Cl)=N\C2=CC=NC=C2.O=C(C3=CC=CN=C3)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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CHS-828 (nicotinate) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CHS-828 (nicotinate)1160589-73-0GMX1778 (nicotinate)NAMPTApoptosisNicotinamide phosphoribosyl transferasePBEFVisfatinpre-B cell-enhancing factorPre-B cell colony enhancing factorInhibitorinhibitorinhibit

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