Cilazaprilat (Synonyms: Ro 31-3113)

Cat. No.: HY-A0113: FAQs
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Cilazaprilat is an inhibitor of angiotensin-converting enzyme (ACE; IC₅₀=0.7 nM for the rat enzyme) and an active metabolite of Cilazapril (HY-A0043). It decreases creatine kinase release in primary neonatal rat cardiac myocytes in an in vitro model of ischemia-reperfusion injury induced by hypoxia and reoxygenation when used at a concentration of 10 μM.3 Intra-arterial administration of cilazaprilat (3 μg/kg per minute) increases coronary blood flow and fractional shortening in a dog model of coronary hypoperfusion-induced myocardial ischemia.

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Cilazaprilat Chemical Structure

CAS No. : 90139-06-3

Size	Price	Stock	Quantity
1 mg	USD 111	Get quote 3 - 4 weeks 4 - 5 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
5 mg	USD 389	Get quote 3 - 4 weeks 4 - 5 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
10 mg	USD 552	Get quote 3 - 4 weeks 4 - 5 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Other Forms of Cilazaprilat:

Cilazaprilat-d₅ Get quote

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Description	Cilazaprilat is an inhibitor of angiotensin-converting enzyme (ACE; IC₅₀=0.7 nM for the rat enzyme) and an active metabolite of Cilazapril (HY-A0043). It decreases creatine kinase release in primary neonatal rat cardiac myocytes in an in vitro model of ischemia-reperfusion injury induced by hypoxia and reoxygenation when used at a concentration of 10 μM.3 Intra-arterial administration of cilazaprilat (3 μg/kg per minute) increases coronary blood flow and fractional shortening in a dog model of coronary hypoperfusion-induced myocardial ischemia.
Molecular Weight	389.45
Formula	C₂₀H₂₇N₃O₅
CAS No.	90139-06-3
SMILES	O=C([C@@H]1CCCN2N1C([C@@H](N[C@H](C(O)=O)CCC3=CC=CC=C3)CCC2)=O)O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (273 KB) Handling Instructions (2659 KB)
References	[1]. Takai, et al. Hydrolytic profile for ester- or amide-linkage by carboxylesterases pI 5.3 and 4.5 from human liver. Bio. Pharm. Bull. 20(8), 869-873 (1997).

Cilazaprilat Related Classifications

Cardiovascular Disease

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cilazaprilat90139-06-3Ro 31-3113Angiotensin-converting Enzyme (ACE)Inhibitorinhibitorinhibit

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Cilazaprilat (Synonyms: Ro 31-3113)

Other Forms of Cilazaprilat:

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Biological Activity

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