Citalopram-d₃ hydrochloride

Cat. No.: HY-121203S4: FAQs
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Citalopram-d₃ hydrochloride is deuterated labeled Citalopram (HY-121203). Citalopram is a racemate mixture of the active S(+)-enantiomer (Escitalopram; HY-14258) and R(-)-enantiomer. Citalopram is an orally active selective serotonin reuptake inhibitor (SSRI). Citalopram is an antidepressant and enhances serotoninergic neurotransmission.

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Citalopram-d<sub>3</sub> hydrochloride Chemical Structure

Citalopram-d₃ hydrochloride Chemical Structure

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1 mg		Get quote	Estimated Time of Arrival: December 31

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Purity & Documentation
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Description	Citalopram-d₃ hydrochloride is deuterated labeled Citalopram (HY-121203). Citalopram is a racemate mixture of the active S(+)-enantiomer (Escitalopram; HY-14258) and R(-)-enantiomer. Citalopram is an orally active selective serotonin reuptake inhibitor (SSRI). Citalopram is an antidepressant and enhances serotoninergic neurotransmission^[1]^[2]^[3].
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. Citalopram (25-175 μM; 24 h) shows a concentration-dependent cytotoxicity^[4]. Citalopram (100 μM; 24 h) strongly down-regulates MYBL2, BIRC5, BARD1, AURKA, CCNA2 and CCNE1 in B104 cells^[4]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Citalopram-d₃ hydrochloride Related Antibodies
In Vivo	Citalopram (5-40?mg/kg; i.p.) reduces immobility time in DBA/2J mice but not in C57BL/6J mice^[5]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight	363.87
Formula	C₂₀H₁₉D₃ClFN₂O
Unlabeled CAS	59729-33-8
SMILES	N#CC1=CC2=C(C(C3=CC=C(F)C=C3)(CCCN(C)C([2H])([2H])[2H])OC2)C=C1.Cl
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (274 KB) Handling Instructions (2659 KB)
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief] [2]. Carlsson B, et al. Enantioselective analysis of citalopram and escitalopram in postmortem blood together with genotyping for CYP2D6 and CYP2C19. J Anal Toxicol. 2009;33(2):65-76. [Content Brief] [3]. Laurent Sakka, et al. Assessment of citalopram and escitalopram on neuroblastoma cell lines. Cell toxicity and gene modulation. Oncotarget. 2017 Jun 27;8(26):42789-42807. [Content Brief] [4]. Milne RJ, et al. Citalopram. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depressive illness. Drugs. 1991;41(3):450-477. [Content Brief] [5]. Zeng-Liang Jin, et al. Mouse strain differences in SSRI sensitivity correlate with serotonin transporter binding and function. Sci Rep. 2017 Aug 17;7(1):8631. [Content Brief]