2. Membrane Transporter/Ion Channel Apoptosis
  3. Na+/K+ ATPase Apoptosis
  4. Citreoviridin

Citreoviridin, a toxin from Penicillium citreoviride NRRL 2579, inhibits brain synaptosomal Na+/K+-ATPase whereas in microsomes, both Na+/K+-ATPase and Mg2+-ATPase activities are significantly stimulated in a dose-dependent manner. Citreoviridin inhibits cell proliferation and enhances apoptosis of human umbilical vein endothelial cells.

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Citreoviridin Chemical Structure

Citreoviridin Chemical Structure

CAS No. : 25425-12-1

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Based on 1 publication(s) in Google Scholar

Other Forms of Citreoviridin:

Citreoviridin Related Antibodies

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Description

Citreoviridin, a toxin from Penicillium citreoviride NRRL 2579, inhibits brain synaptosomal Na+/K+-ATPase whereas in microsomes, both Na+/K+-ATPase and Mg2+-ATPase activities are significantly stimulated in a dose-dependent manner[1]. Citreoviridin inhibits cell proliferation and enhances apoptosis of human umbilical vein endothelial cells[2].

IC50 & Target

Na+/K+-ATPase[1]
Apoptosis[2]
Cellular Effect
Cell Line Type Value Description References
A549 IC50
1.5 μM
Compound: Citreoviridin
Antiproliferative activity against human A549 cells assessed as reduction in cell proliferation incubated for 48 hrs by xCELLigence RTCA system analysis
Antiproliferative activity against human A549 cells assessed as reduction in cell proliferation incubated for 48 hrs by xCELLigence RTCA system analysis
[PMID: 32942072]
CL1-0 IC50
1.5 μM
Compound: Citreoviridin
Antiproliferative activity against human CL1-0 cells assessed as reduction in cell proliferation incubated for 48 hrs by xCELLigence RTCA system analysis
Antiproliferative activity against human CL1-0 cells assessed as reduction in cell proliferation incubated for 48 hrs by xCELLigence RTCA system analysis
[PMID: 32942072]
Molecular Weight

402.48

Formula

C23H30O6
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CC(/C=C/C=C/C=C/C(O1)=C(C(OC)=CC1=O)C)=C\[C@]2([C@H](O)[C@]([C@H](O2)C)(O)C)C
Structure Classification
Initial Source

Penicillium citreoviride
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Methanol : 10 mg/mL (24.85 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4846 mL 12.4230 mL 24.8460 mL
5 mM 0.4969 mL 2.4846 mL 4.9692 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Methanol 1 mM 2.4846 mL 12.4230 mL 24.8460 mL 62.1149 mL
5 mM 0.4969 mL 2.4846 mL 4.9692 mL 12.4230 mL
10 mM 0.2485 mL 1.2423 mL 2.4846 mL 6.2115 mL
15 mM 0.1656 mL 0.8282 mL 1.6564 mL 4.1410 mL
20 mM 0.1242 mL 0.6211 mL 1.2423 mL 3.1057 mL
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Citreoviridin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Citreoviridin25425-12-1Na+/K+ ATPaseApoptosisSodium potassium pumpInhibitorinhibitorinhibit

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