2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. Cl-HIBO

Cl-HIBO is a highly subtype-selective GluR1/2 agonist (EC50=4.7 and 1.7 μM, respectively). Cl-HIBO is a potent AMPA receptor agonist (IC50=0.22 μM). Cl-HIBO has desensitizing properties.

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Cl-HIBO Chemical Structure

Cl-HIBO Chemical Structure

CAS No. : 909400-43-7

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Cl-HIBO Related Antibodies

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Description

Cl-HIBO is a highly subtype-selective GluR1/2 agonist (EC50=4.7 and 1.7 μM, respectively). Cl-HIBO is a potent AMPA receptor agonist (IC50=0.22 μM). Cl-HIBO has desensitizing properties[1].

IC50 & Target

EC50: 4.7, 1.7, 2700 and 1300 μM=GluR1/2/3/4[1]
In Vitro

Cl-HIBO is a strongly desensitizing full agonist at GluR1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cl-HIBO Related Antibodies
Molecular Weight

206.58

Formula

C6H7ClN2O4
CAS No.
SMILES

O=C(O)C(N)CC(ON1)=C(Cl)C1=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Cl-HIBO Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cl-HIBO909400-43-7iGluRIonotropic glutamate receptorssubtypeselectivedesensitizingneurotoxicityInhibitorinhibitorinhibit

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