Cl-HIBO

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Cl-HIBO is a highly subtype-selective GluR1/2 agonist (EC₅₀=4.7 and 1.7 μM, respectively). Cl-HIBO is a potent AMPA receptor agonist (IC₅₀=0.22 μM). Cl-HIBO has desensitizing properties.

For research use only. We do not sell to patients.

Cl-HIBO Chemical Structure

CAS No. : 909400-43-7

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

EC50: 4.7, 1.7, 2700 and 1300 μM=GluR1/2/3/4^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
Oocyte	EC₅₀	1.7 μM Compound: 3 (Cl-HIBO)	Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 2 (GluR2) using rat cortical slice model in Xenopus laevis oocytes Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 2 (GluR2) using rat cortical slice model in Xenopus laevis oocytes	[PMID: 12747796]
Oocyte	EC₅₀	1.7 μM Compound: 3, Cl-HIBO	Agonist activity at rat recombinant GluA2(Q)i expressed in Xenopus laevis oocytes by two-electrode voltage clamp assay Agonist activity at rat recombinant GluA2(Q)i expressed in Xenopus laevis oocytes by two-electrode voltage clamp assay	[PMID: 21067182]
Oocyte	EC₅₀	1300 μM Compound: 3 (Cl-HIBO)	Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 4 (GluR4) using rat cortical slice model in Xenopus laevis oocytes Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 4 (GluR4) using rat cortical slice model in Xenopus laevis oocytes	[PMID: 12747796]
Oocyte	EC₅₀	1300 μM Compound: 3, Cl-HIBO	Agonist activity at rat recombinant GluA4i expressed in Xenopus laevis oocytes by two-electrode voltage clamp assay Agonist activity at rat recombinant GluA4i expressed in Xenopus laevis oocytes by two-electrode voltage clamp assay	[PMID: 21067182]
Oocyte	EC₅₀	2700 μM Compound: 3 (Cl-HIBO)	Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 3 (GluR3) using rat cortical slice model in Xenopus laevis oocytes Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 3 (GluR3) using rat cortical slice model in Xenopus laevis oocytes	[PMID: 12747796]
Oocyte	EC₅₀	2700 μM Compound: 3, Cl-HIBO	Agonist activity at rat recombinant GluA3i expressed in Xenopus laevis oocytes by two-electrode voltage clamp assay Agonist activity at rat recombinant GluA3i expressed in Xenopus laevis oocytes by two-electrode voltage clamp assay	[PMID: 21067182]
Oocyte	EC₅₀	4.7 μM Compound: 3 (Cl-HIBO)	Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 1 (GluR1) using rat cortical slice model in Xenopus laevis oocytes Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 1 (GluR1) using rat cortical slice model in Xenopus laevis oocytes	[PMID: 12747796]
Oocyte	EC₅₀	4.7 μM Compound: 3, Cl-HIBO	Agonist activity at rat recombinant GluA1i expressed in Xenopus laevis oocytes by two-electrode voltage clamp assay Agonist activity at rat recombinant GluA1i expressed in Xenopus laevis oocytes by two-electrode voltage clamp assay	[PMID: 21067182]

In Vitro

Cl-HIBO is a strongly desensitizing full agonist at GluR1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

206.58

Formula

C₆H₇ClN₂O₄

CAS No.

909400-43-7

SMILES

O=C(O)C(N)CC(ON1)=C(Cl)C1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Bjerrum EJ, et al. Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO). J Med Chem. 2003;46(11):2246-2249. [Content Brief]

Cl-HIBO Related Classifications

Neurological Disease

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cl-HIBO909400-43-7iGluRIonotropic glutamate receptorssubtypeselectivedesensitizingneurotoxicityInhibitorinhibitorinhibit

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