CLB-016

Cat. No.: HY-113662: FAQs
Data Sheet Handling Instructions

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CLB-016 is a potent Hypoxia-inducible factor (HIF-1) inhibitor with an IC₅₀ of 19.1 μM. CLB-016 significantly suppresses HIF-1-mediated hypoxia response.

For research use only. We do not sell to patients.

CLB-016 Chemical Structure

CAS No. : 1005636-29-2

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HIF-1α HIF

Biological Activity
Purity & Documentation
References
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Description

CLB-016 is a potent Hypoxia-inducible factor (HIF-1) inhibitor with an IC₅₀ of 19.1 μM. CLB-016 significantly suppresses HIF-1-mediated hypoxia response^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HT-1080	IC₅₀	15.1 μM Compound: 1, CLB-016	Inhibition of cell proliferation of human HT1080 cells after 72 hrs by WST-8 dye based cell counting assay Inhibition of cell proliferation of human HT1080 cells after 72 hrs by WST-8 dye based cell counting assay	[PMID: 25773014]
HT-1080	IC₅₀	19.1 μM Compound: 1, CLB-016	Inhibition of HIF1 in human HT1080 cells transfected with 5xHRE/pGL3/VEGF/E1b reporter plasmid pre-incubated for 1 hr followed by incubation under hypoxia conditions for 24 hrs by HRE-driven luciferase reporter gene assay Inhibition of HIF1 in human HT1080 cells transfected with 5xHRE/pGL3/VEGF/E1b reporter plasmid pre-incubated for 1 hr followed by incubation under hypoxia conditions for 24 hrs by HRE-driven luciferase reporter gene assay	[PMID: 25773014]

Molecular Weight

356.38

Formula

C₁₇H₂₀N₆O₃

CAS No.

1005636-29-2

SMILES

O=C(C1=NN(CC)C=C1NC(C2=CC=C(CN3N=C(C)C=C3C)O2)=O)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yasuda Y, et al. Design, synthesis, and structure-activity relationships of 1-ethylpyrazole-3-carboxamide compounds as novel hypoxia-inducible factor (HIF)-1 inhibitors. Bioorg Med Chem. 2015 Apr 15;23(8):1776-87. [Content Brief]

CLB-016 Related Classifications

Molarity Calculator
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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CLB-0161005636-29-2CLB016CLB 016HIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHHIFhypoxia-inducible factorInhibitorinhibitorinhibit

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