2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. CP-96,345

CP-96,345 is a specific, highly potent, and orally active tachykinin and substance P receptor non-peptide inhibitor. CP-96,345 prevents the drop in blood pressure evoked by substance P and neurokinin A. CP-96,345 can be used for researching neurogenic inflammation.

For research use only. We do not sell to patients.

CP-96,345 Chemical Structure

CP-96,345 Chemical Structure

CAS No. : 132746-60-2

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Based on 1 publication(s) in Google Scholar

CP-96,345 Related Antibodies

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Description

CP-96,345 is a specific, highly potent, and orally active tachykinin and substance P receptor non-peptide inhibitor. CP-96,345 prevents the drop in blood pressure evoked by substance P and neurokinin A. CP-96,345 can be used for researching neurogenic inflammation[1].

IC50 & Target

Tachykinin, Substance P receptor[1]
Cellular Effect
Cell Line Type Value Description References
A549 IC50
46.83 μM
Compound: CP-96345
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
[PMID: 28710964]
CHO IC50
0.2 nM
Compound: 1, (CP-96345)
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
[PMID: 8393115]
CHO IC50
0.45 nM
Compound: CP-96345
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
[PMID: 7535362]
CHO IC50
0.5 nM
Compound: CP-96345
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
[PMID: 7535362]
CHO IC50
22 nM
Compound: CP-96345
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
[PMID: 7535362]
IM-9 IC50
0.33 nM
Compound: CP-96345
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
10.1016/0960-894X(96)00148-5
IM-9 IC50
0.35 nM
Compound: 1
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
[PMID: 8576917]
IM-9 IC50
0.48 nM
Compound: 1
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
[PMID: 7520943]
IM-9 IC50
0.52 nM
Compound: CP-96345
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
10.1016/S0960-894X(01)80246-8
IM-9 IC50
0.77 nM
Compound: 3, (CP-96345)
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
[PMID: 1378901]
MRC5 IC50
57.9 μM
Compound: CP-96345
Cytotoxicity against human MRC5 cells after 48 hrs by MTT assay
Cytotoxicity against human MRC5 cells after 48 hrs by MTT assay
[PMID: 28710964]
Molecular Weight

412.57

Formula

C28H32N2O
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

COC1=C(C=CC=C1)CN[C@@H]2[C@@H](N3CCC2CC3)C(C4=CC=CC=C4)C5=CC=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥99.0%

SDS (537 KB)

COA (255 KB)

Handling Instructions (2659 KB)
References
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CP-96,345 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CP-96,345132746-60-2Neurokinin ReceptorNK receptorTachykinin receptorNeurogenic inflammationOrally activeBlood pressureSubstance P receptorTachykininInhibitorinhibitorinhibit

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