CS-003 

CS-003 is a triple neurokinin receptor antagonist with activity in inhibiting neurokinin-related respiratory diseases. CS-003 exhibits high affinity for human neurokinin 1, 2 and 3 receptors, withK_i values of 2.3 nM, 0.54 nM and 0.74 nM respectively. The K_i values of CS-003 on the guinea pig neurokinin receptor are 5.2 nM, 0.47 nM and 0.71 nM respectively, showing superior inhibitory effect. CS-003 significantly inhibits the formation of inositol phosphate involving substance P, neurokinin A and neurokinin B through competitive antagonism. CS-003 significantly inhibits citric acid-induced cough, and its effect is better than other selective neurokinin receptor antagonists^[1].

710.11

C₃₄H₃₉Cl₃N₂O₆S

216776-73-7

O=S1C2(CCN(CC2)CC[C@@]3(C4=CC(Cl)=C(C=C4)Cl)CN(CCO3)C(C5=CC(OC)=C(C(OC)=C5)OC)=O)C6=CC=CC=C6C1.Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Novel triple neurokinin receptor antagonist CS-003 strongly inhibits neurokinin related responses  [Content Brief]