CSF1R-IN-15 

CSF1R-IN-15 (compound 23) is an inhibitor targeting CSF1R. The colony-stimulating factor-1 receptor (CSF1R) is a tyrosine kinase embedded in the cell membrane of macrophages. The receptor is activated by colony-stimulating factor-1 (CSF-1) and interleukin-34, and signaling via CSF1R is crucial for the differentiation, proliferation, and survival of macrophages^[1].

CSF1R-IN-15 (0.007-10 μM, 72 h) is inactive to Ba/F3 cell viability, while Pex significantly (HY-16749) showed superior activity ^[1].
CSF1R-IN-15 assessment of plasma protein binding is measured by equilibrium dialysis. CSF1R-IN-15 (5 μM, 6 h, 37 °C) was incubated with plasma and showed 69% binding to mouse plasma proteins^[1].
Pharmacokinetic Analysis for CSF1R-IN-15 (compound 23) in vitro^[1]

CSF1R-IN-15 (compound 23) 体外药代动力学分析^[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In vivo pharmacokinetic indices were derived from cassette dosing studies. The t_1/2, C₀, AUC_0-∞, CL_obs, and V_ss,obs of CSF1R-IN-15 were 0.5 h, 37 ng/mL, 18 h*ng/mL, 54 L/h/kg, and 32 L/kg in C57BLKS mice^[1].
Pharmacokinetic Analysis in CSF1R-IN-15 (compound 23) for a cassette dosing study in C57BLKS mice^[1]

CSF1R-IN-15 (compound 23) 在 C57BLKS 小鼠中的体内药代动力学分析^[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

358.44

C₂₂H₂₂N₄O

2925744-43-8

CN(C1=NC=NC2=C1C=C(N2)C3=CC=C(C=C3)CO)CC4=CC=CC(C)=C4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Aarhus TI, et al. Synthesis and Development of Highly Selective Pyrrolo[2,3-d]pyrimidine CSF1R Inhibitors Targeting the Autoinhibited Form. J Med Chem. 2023 May 25;66(10):6959-6980.  [Content Brief]