2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. CTAP TFA

CTAP TFA is a potent, highly selective, and BBB penetrant μ opioid receptor antagonist, with an IC50 of 3.5 nM. CTAP TFA displays over 1200-fold selectivity over δ opioid (IC50=4500 nM) and somatostatin receptors. CTAP TFA can be used for the study of L-DOPA-induced dyskinesia (LID) and opiate overdose or addiction.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

CTAP TFA Chemical Structure

CTAP TFA Chemical Structure

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1 mg USD 220 In-stock
5 mg USD 550 In-stock
10 mg USD 930 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of CTAP TFA:

CTAP TFA Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE CTAP TFA

View All Opioid Receptor Isoform Specific Products:

View All Isoforms
μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

CTAP TFA is a potent, highly selective, and BBB penetrant μ opioid receptor antagonist, with an IC50 of 3.5 nM. CTAP TFA displays over 1200-fold selectivity over δ opioid (IC50=4500 nM) and somatostatin receptors. CTAP TFA can be used for the study of L-DOPA-induced dyskinesia (LID) and opiate overdose or addiction[1][2].

IC50 & Target

μ Opioid Receptor/MOR

3.5 nM (IC50)

δ Opioid Receptor/DOR

4500 nM (IC50)

In Vivo

CTAP TFA (0-1 mg/kg, IP, single) blocks morphine’s antinociceptive effect[1].
CTAP TFA (10 mg/kg; IP, single) has no effect on L-DOPA-induced limb, axial, orolingual, or locomotor abnormal involuntary movements[1].
CTAP TFA is stable in the blood and serum of rats (T1/2 > 500 min), showing that the structure of this peptide offers enzymatic resistance[2].
CTAP TFA is extensively protein-bound to albumin in the perfusion medium (68.2%) and to proteins in rat serum (84.2%)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats[1]
Dosage: 0, 0.1, 0.5, 1 mg/kg
Administration: IP, single
Result: Completely blocked morphine’s antinociceptive effect at 0.5 or 1 mg/kg.
Molecular Weight

1218.32

Formula

C53H70F3N13O12S2
Appearance

Solid

Color

White to off-white

Sequence

Phe-Cys-Tyr-Trp-Arg-Thr-Pen-Thr-NH2 (Disulfide bridge:Cys2-Pen7)
Sequence Shortening

FCYWRT{Pen}T-NH2 (Disulfide bridge:Cys2-Pen7)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (82.08 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8208 mL 4.1040 mL 8.2080 mL
5 mM 0.1642 mL 0.8208 mL 1.6416 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.56%

COA (247 KB) LCMS (242 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.8208 mL 4.1040 mL 8.2080 mL 20.5201 mL
5 mM 0.1642 mL 0.8208 mL 1.6416 mL 4.1040 mL
10 mM 0.0821 mL 0.4104 mL 0.8208 mL 2.0520 mL
15 mM 0.0547 mL 0.2736 mL 0.5472 mL 1.3680 mL
20 mM 0.0410 mL 0.2052 mL 0.4104 mL 1.0260 mL
25 mM 0.0328 mL 0.1642 mL 0.3283 mL 0.8208 mL
30 mM 0.0274 mL 0.1368 mL 0.2736 mL 0.6840 mL
40 mM 0.0205 mL 0.1026 mL 0.2052 mL 0.5130 mL
50 mM 0.0164 mL 0.0821 mL 0.1642 mL 0.4104 mL
60 mM 0.0137 mL 0.0684 mL 0.1368 mL 0.3420 mL
80 mM 0.0103 mL 0.0513 mL 0.1026 mL 0.2565 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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CTAP TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CTAPOpioid Receptorsomatostatin receptorμ-opioid Receptorδ opioidL-DOPADyskinesiaParkinson’s diseasePDInhibitorinhibitorinhibit

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