Cyclic GMP-¹³C,¹⁵N₂  (Synonyms: Guanosine 3',5'-cyclic-¹³C,¹⁵N₂ monophosphate)

Cyclic GMP-¹³C,¹⁵N₂ is ¹³C and ¹⁵N labeled Cyclic GMP. Cyclic GMP (cGAMP) is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP activates the stimulator of interferon genes (STING), activating a signaling cascade that leads to the production of type I interferons and other immune mediators^[1][2][3].

348.18

C₉¹³CH₁₂N₃¹⁵N₂O₇P

7665-99-8

O=P1(OC[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C3N=[13C]([15NH2])[15NH]C4=O)O)O1)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Wu J, et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science. 2013 Feb 15;339(6121):826-30.  [Content Brief]

  [3]. Ablasser A, et al. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP. Nature. 2013 Nov 28;503(7477):530-4.  [Content Brief]