Cyclic L27-11 

Cyclic L27-11 is a cyclic peptide-like antibiotic with strong antibacterial activity against specific bacteria such as Pseudomonas sp. Cyclic L27-11 shows nanomolar antibacterial activity against Pseudomonas sp., especially Pseudomonas aeruginosa. Cyclic L27-11 interferes with the function of bacterial outer membrane protein LptD, preventing the normal transport of lipopolysaccharide (LPS), leading to the accumulation of membrane-like substances in bacterial cells, which in turn affects the survival of bacteria. Cyclic L27-11 can be used in the development of antibacterial agents^[1].

1805.22

C₈₇H₁₄₁N₂₇O₁₅

1221423-80-8

cyclo(Thr-Trp-Leu-Lys-Lys-Arg-Arg-Trp-Lys-Lys-Ala-Lys-{d-Pro}-Pro)

cyclo(TWLKKRRWKKAK-{d-Pro}-P)

O=C1N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N2[C@@H](C(N3[C@H](C(N[C@H]1[C@@H](C)O)=O)CCC3)=O)CCC2)=O)CCCCN)=O)C)=O)CCCCN)=O)CCCCN)=O)CC4=CNC5=CC=CC=C45)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCCN)=O)CCCCN)=O)CC(C)C)=O)CC6=CNC7=CC=CC=C67

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Schmidt J, et al. Structural studies of β-hairpin peptidomimetic antibiotics that target LptD in Pseudomonas sp[J]. Bioorganic & medicinal chemistry, 2013, 21(18): 5806-5810.  [Content Brief]