2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. Cyprodime hydrochloride

Cyprodime hydrochloride is a highly selective μ-opioid receptor antagonist with Ki values of 5.4 nM, 244.6 nM and 2187 nM for μ-, δ- and κ-opioid receptors, respectively. Cyprodime hydrochloride has anti-depressant-like effect.

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Cyprodime hydrochloride Chemical Structure

Cyprodime hydrochloride Chemical Structure

CAS No. : 2387505-50-0

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Other Forms of Cyprodime hydrochloride:

Cyprodime hydrochloride Related Antibodies

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Description

Cyprodime hydrochloride is a highly selective μ-opioid receptor antagonist with Ki values of 5.4 nM, 244.6 nM and 2187 nM for μ-, δ- and κ-opioid receptors, respectively. Cyprodime hydrochloride has anti-depressant-like effect[1][2].

IC50 & Target

Ki: 5.4 nM (μ-opioid), 244.6 nM (δ-opioid) and 2187 nM (κ-opioid)[1]
In Vitro

Cyprodime hydrochloride has Ki values of 8.1 nM and 26.6 nM for μ-opioid receptor in rat brain (Wistar) and guinea pig brain[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cyprodime hydrochloride Related Antibodies
In Vivo

Cyprodime hydrochloride (3, 10?mg/kg; i.p.; 60?min prior to test) significantly increases immobility time in the forced swimming test (FST) with higher dose of 10?mg/kg. Cyprodime hydrochloride increases the grooming time[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male NMRI mice aged 21-25 days and weighing 10-12 g[2]
Dosage: 3, 10 mg/kg
Administration: IP; 60 min prior to test
Result: Significantly increased immobility time in the forced swimming test (FST) with higher dose of 10 mg/kg.
Molecular Weight

391.93

Formula

C22H30ClNO3
CAS No.
SMILES

CO[C@@]12[C@]3(CC(CC2)=O)C4=C(OC)C=CC=C4C[C@@]1([H])N(CC5CC5)CC3.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Cyprodime hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyprodime2387505-50-0Opioid Receptoranti-depressantimmobilitytimeforcedswimmingdepressantInhibitorinhibitorinhibit

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