d-(KLAKLAK)2, Proapoptotic Peptide

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d-(KLAKLAK)2, as an antibacterial and anti-tumor polypeptide, is a representative of the antimicrobial peptide group, and also has good anticancer properties. d-(KLAKLAK)2 is able to kill bacteria by damaging their cell membranes, causing cell contents to leak out. d-(KLAKLAK)2 can also inhibit tumor cell proliferation by causing mitochondrial swelling and mitochondrial membrane destruction, triggering apoptosis (programmed cell death).

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d-(KLAKLAK)2, Proapoptotic Peptide Chemical Structure

CAS No. : 721397-24-6

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Description	d-(KLAKLAK)2, as an antibacterial and anti-tumor polypeptide, is a representative of the antimicrobial peptide group, and also has good anticancer properties. d-(KLAKLAK)2 is able to kill bacteria by damaging their cell membranes, causing cell contents to leak out. d-(KLAKLAK)2 can also inhibit tumor cell proliferation by causing mitochondrial swelling and mitochondrial membrane destruction, triggering apoptosis (programmed cell death)^[1].
Molecular Weight	1523.01
Formula	C₇₂H₁₃₉N₂₁O₁₄
CAS No.	721397-24-6
Sequence	{d-(Lys-Leu-Ala-Lys-Leu-Ala-Lys-Lys-Leu-Ala-Lys-Leu-Ala-Lys)}-NH2
Sequence Shortening	{d-(KLAKLAKKLAKLAK)}-NH2
SMILES	O=C([C@H](N)CCCCN)N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N)=O)CCCCN)=O)C)=O)CC(C)C)=O)CCCCN)=O)C)=O)CC(C)C)=O)CCCCN)=O)CCCCN)=O)C)=O)CC(C)C)=O)CCCCN)=O)C)=O)CC(C)C
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (257 KB) Handling Instructions (2659 KB)
References	[1]. Jaber S, et al. Synthesis, antitumor and antibacterial studies of new shortened analogues of (KLAKLAK) 2-NH2 and their conjugates containing unnatural amino acids[J]. Molecules, 2021, 26(4): 898. [Content Brief]