(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B

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(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B is a competitive antagonist of Neurokinin B (Neurokinin Receptor) with a pA2 of 5.5. (D-Pro2,D-Trp6,8,Nle10)-Neurokinin B shows no influence on Substance P or Neurokinin A.

For research use only. We do not sell to patients.

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(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B Chemical Structure

CAS No. : 109212-72-8

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Description	(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B is a competitive antagonist of Neurokinin B (Neurokinin Receptor) with a pA2 of 5.5. (D-Pro2,D-Trp6,8,Nle10)-Neurokinin B shows no influence on Substance P or Neurokinin A^[1].
In Vivo	(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B (1 mg/kg i.v.) significantly reduces Substance P- and Neurokinin B- but not acetylcholine- or Neurokinin A-induced salivation. (D-Pro2,D-Trp6,8,Nle10)-Neurokinin B lowers blood pressure in anesthetized rats by 35 to 40%^[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight	1326.50
Formula	C₆₇H₈₇N₁₅O₁₄
CAS No.	109212-72-8
Sequence Shortening	D-{D-Pro}-HDF-{D-Trp}-V-{D-Trp}-L-{Nle}-NH2
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (259 KB) Handling Instructions (2659 KB)
References	[1]. H I Jacoby, et al. Differentiation of multiple neurokinin receptors in the guinea pig ileum. Life Sci. 1986 Nov 24;39(21):1995-2003. [Content Brief] [2]. C W Murray, et al. Neurokinin-induced salivation in the anesthetized rat: a three receptor hypothesis. J Pharmacol Exp Ther. 1987 Aug;242(2):500-6. [Content Brief]