[D-Trp7,9,10]-Substance P TFA

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[D-Trp7,9,10]-Substance P TFA is a substance P analogue. Substance P stimulates substance P receptors but also inhibits ion conductance through nicotinic acetylcholine receptors.

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[D-Trp7,9,10]-Substance P TFA Chemical Structure

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Other Forms of [D-Trp7,9,10]-Substance P TFA:

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Biological Activity
Purity & Documentation
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Description	[D-Trp7,9,10]-Substance P TFA is a substance P analogue. Substance P stimulates substance P receptors but also inhibits ion conductance through nicotinic acetylcholine receptors^[1].
In Vitro	Substance P (SP)-related peptide, pGlu-Gln-D-Trp-Phe-D-Trp-D-Trp-Met-NH2, inhibits the activation of G_i or G_o by M2 muscarinic cholinergic receptor (M2 mAChR) or of Gs by beta-adrenergic receptor in the reconstituted phospholipid vesicles, assayed by receptor-promoted GTP hydrolysis^[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. [D-Trp7,9,10]-Substance P TFA Related Antibodies
Molecular Weight	1588.88 (free base)
Formula	C₇₉H₁₀₅N₂₁O₁₃S.xC₂HF₃O₂
Sequence	Arg-Pro-Lys-Pro-Gln-Gln-Trp-Phe-Trp-Trp-Met-NH2
Sequence Shortening	RPKPQQWFWWM-NH2
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (265 KB) Handling Instructions (2659 KB)
References	[1]. Eardley D, et al. Both substance P agonists and antagonists inhibit ion conductance through nicotinic acetylcholine receptors on PC12 cells. Eur J Pharmacol. 1985;114(1):101-104. [Content Brief] [2]. Mukai H, et al. G protein antagonists. A novel hydrophobic peptide competes with receptor for G protein binding. J Biol Chem. 1992;267(23):16237-16243. [Content Brief]