2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. DA-6886 monohydrochloride

DA-6886 is a 5-Hydroxytryptamine receptor 4 (5-HT4) agonist. DA-6886 induces relaxation of the rat oesophagus preparation in a 5-HT4 receptor antagonist-sensitive manner. The evaluation of DA-6886 in CHO cells expressing hERG channels reveals that it inhibits hERG channel current with an pIC50 value of 4.3, indicating that the compound is 1000-fold more selective for the 5-HT4 receptor over hERG channels. DA-6886 can be used in the study of constipated irritable bowel syndrome.

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DA-6886 monohydrochloride Chemical Structure

DA-6886 monohydrochloride Chemical Structure

CAS No. : 1645260-76-9

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DA-6886 monohydrochloride Related Antibodies

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Description

DA-6886 is a 5-Hydroxytryptamine receptor 4 (5-HT4) agonist. DA-6886 induces relaxation of the rat oesophagus preparation in a 5-HT4 receptor antagonist-sensitive manner. The evaluation of DA-6886 in CHO cells expressing hERG channels reveals that it inhibits hERG channel current with an pIC50 value of 4.3, indicating that the compound is 1000-fold more selective for the 5-HT4 receptor over hERG channels. DA-6886 can be used in the study of constipated irritable bowel syndrome[1][2].

IC50 & Target

5-HT4 Receptor

4.3 (pIC50)

Molecular Weight

443.37

Formula

C19H28Cl2N6O2
CAS No.
SMILES

O=C(NCC1CCN(CCCN2N=NC=C2)CC1)C3=CC(Cl)=C(N)C=C3OC.Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DA-6886 monohydrochloride Related Classifications

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Keywords:

DA-6886 monohydrochloride1645260-76-95-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorGPCR/G ProteinNeuroscienceSelectiveIrritable Bowel SyndromeInhibitorinhibitorinhibit

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