DALDA TFA 

DALDA TFA is a potent and highly selective μ-opioid receptor agonist with a K_i of 1.69 nM. DALDA TFA shows antinociceptive and respiratory effects^[1].

DALDA carrys a net positive charge (3+) at physiological pH and is thus hydrophilic and more polar than morphine^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DALDA (0-7 nmol/rat; i.t.; once) shows antinociceptive and respiratory effects in rats^[1].
DALDA (0.1 and 1.0 μg/side; ICV; once) results in biphasic effects, with an initial suppression, an intermediate marked inhibition, followed by activation for horizontal movement, rearing and stereotypy times in rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

611.74 (free base)

C₃₀H₄₅N₉O₅.xC₂HF₃O₂

Tyr-{d-Arg}-Phe-Lys-NH2

Y-{d-Arg}-FK-NH2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Shimoyama M, et al. Antinociceptive and respiratory effects of intrathecal H-Tyr-D-Arg-Phe-Lys-NH2 (DALDA) and [Dmt1] DALDA. Journal of Pharmacology and Experimental Therapeutics, 2001, 297(1): 364-371.  [Content Brief]

  [2]. Meyer ME, et al. DALDA (H-Tyr-D-Arg-Phe-Lys-NH2), a potent mu-opioid peptide agonist, affects various patterns of locomotor activities. Pharmacol Biochem Behav. 1995 May;51(1):149-51.  [Content Brief]