2. PROTAC Epigenetics
  3. PROTACs Epigenetic Reader Domain
  4. DAO-dBET1

DAO-dBET1 is a potent BRD4 degrader with a DC50 value of 277 nM in the presence of CoCl2. DAO-dBET1 inhibits hypoxia and Cath-L trigger with an IC50 value of 281 nM.

For research use only. We do not sell to patients.

DAO-dBET1 Chemical Structure

DAO-dBET1 Chemical Structure

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DAO-dBET1 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

DAO-dBET1 is a potent BRD4 degrader with a DC50 value of 277 nM in the presence of CoCl2. DAO-dBET1 inhibits hypoxia and Cath-L trigger with an IC50 value of 281 nM[1].

Molecular Weight

1295.85

Formula

C65H71ClN12O13S
SMILES

CC1=C(C)C(C(C2=CC=C(Cl)C=C2)=N[C@H]3CC(N(CC4=CC=C([N+]([O-])=O)C=C4)CCCCN(C(COC5=C6C(C(N(C7C(NC(CC7)=O)=O)C6=O)=O)=CC=C5)=O)CC8=CC=C(NC([C@@H](NC(OC(C)(C)C)=O)CCCCNC(C)=O)=O)C=C8)=O)=C(S1)N9C3=NN=C9C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DAO-dBET1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DAO-dBET1PROTACsEpigenetic Reader DomainPROTACBRD4,Inhibitorinhibitorinhibit

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DAO-dBET1
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HY-173255
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