1. GPCR/G Protein Neuronal Signaling
  2. Neurokinin Receptor
  3. Dapitant

Dapitant (RPR 100893) is a non-peptide Substance P antagonist with high affinity for the human NK1 receptor. It belongs to the 7,7,4-trimethylperhydroisoindole class of compounds. Dapitant inhibits the binding of Substance P to NK1 receptors, thereby blocking its neurokinin-mediated effects. This novel antagonist represents a potential therapeutic option for conditions involving Substance P, such as neurogenic inflammation and pain modulation.

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Dapitant Chemical Structure

Dapitant Chemical Structure

CAS No. : 153438-49-4

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Description

Dapitant (RPR 100893) is a non-peptide Substance P antagonist with high affinity for the human NK1 receptor. It belongs to the 7,7,4-trimethylperhydroisoindole class of compounds. Dapitant inhibits the binding of Substance P to NK1 receptors, thereby blocking its neurokinin-mediated effects. This novel antagonist represents a potential therapeutic option for conditions involving Substance P, such as neurogenic inflammation and pain modulation[1].

Molecular Weight

561.71

Formula

C37H39NO4

CAS No.
SMILES

COC1=CC=CC=C1[C@]2(O)CCC(C3=CC=CC=C3)(C4=CC=CC=C4)[C@]5([H])[C@@]2([H])CN(C([C@@H](C)C6=C(OC)C=CC=C6)=O)C5

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Dapitant
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HY-17012
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