(E/Z)-Daporinad hydrochloride (Synonyms: (E/Z)-FK866 hydrochloride; (E/Z)-APO866 hydrochloride)

Cat. No.: HY-110319: FAQs
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(E/Z)-Daporinad hydrochloride ((E/Z)-FK866 hydrochloride) is a potent inhibitor of nicotinamide phosphoribose transferase (NAMPT). (E/Z)-Daporinad hydrochloride induces apoptosis by specifically inhibiting NAMPT to gradually deplete intracellular NAD⁺. (E/Z)-Daporinad hydrochloride can be used in the study of cancer biology and inflammatory diseases.

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(E/Z)-Daporinad hydrochloride Chemical Structure

CAS No. : 1785666-54-7

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Description	(E/Z)-Daporinad hydrochloride ((E/Z)-FK866 hydrochloride) is a potent inhibitor of nicotinamide phosphoribose transferase (NAMPT). (E/Z)-Daporinad hydrochloride induces apoptosis by specifically inhibiting NAMPT to gradually deplete intracellular NAD⁺. (E/Z)-Daporinad hydrochloride can be used in the study of cancer biology and inflammatory diseases^[1].
Molecular Weight	427.97
Formula	C₂₄H₃₀ClN₃O₂
CAS No.	1785666-54-7
SMILES	O=C(N1CCC(CC1)CCCCNC(/C=C/C2=CN=CC=C2)=O)C3=CC=CC=C3.Cl
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (263 KB) Handling Instructions (2659 KB)
References	[1]. Qu S D, Liu G X. Daporinad in vitro metabolite profiling via rat, dog, monkey and human liver microsomes by liquid chromatography/quadrupole‐orbitrap mass spectrometry[J]. Rapid Communications in Mass Spectrometry, 2021, 35(18): e9150. [Content Brief]

(E/Z)-Daporinad hydrochloride Related Classifications

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	×		=		×
C1		V1		C2		V2

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E/Z)-Daporinad1785666-54-7(E/Z)-FK866(E/Z)-APO866NAMPTApoptosisNicotinamide phosphoribosyl transferasePBEFVisfatinpre-B cell-enhancing factorPre-B cell colony enhancing factorapoptosisinflammationcancerInhibitorinhibitorinhibit

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(E/Z)-Daporinad hydrochloride (Synonyms: (E/Z)-FK866 hydrochloride; (E/Z)-APO866 hydrochloride)

Other Forms of (E/Z)-Daporinad hydrochloride:

(E/Z)-Daporinad hydrochloride Related Antibodies

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity

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References

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