2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Darexaban maleate

Darexaban maleate  (Synonyms: YM150 maleate)

Cat. No.: HY-135541
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Darexaban maleate (YM150 maleate) is a direct factor Xa inhibitor with activity in preventing venous thromboembolism. The major metabolite of Darexaban maleate in humans is Darexaban glucitol, which acts pharmacologically. The glucitolation reaction of Darexaban maleate is mainly catalyzed by UGT1A9 and UGT1A10 in the human liver and intestine. The K(m) value of Darexaban maleate glucitolation in the liver is greater than 250 μM, while in the intestine it exhibits substrate inhibition kinetics with a K(m) value of 27.3 μM. The unbound K(m) value of Darexaban maleate is significantly reduced by the influence of fatty acid-free bovine serum albumin in both HLM and UGT1A9.

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Darexaban maleate Chemical Structure

Darexaban maleate Chemical Structure

CAS No. : 365462-24-4

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Darexaban maleate Related Antibodies

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Description

Darexaban maleate (YM150 maleate) is a direct factor Xa inhibitor with activity in preventing venous thromboembolism. The major metabolite of Darexaban maleate in humans is Darexaban glucitol, which acts pharmacologically. The glucitolation reaction of Darexaban maleate is mainly catalyzed by UGT1A9 and UGT1A10 in the human liver and intestine. The K(m) value of Darexaban maleate glucitolation in the liver is greater than 250 μM, while in the intestine it exhibits substrate inhibition kinetics with a K(m) value of 27.3 μM. The unbound K(m) value of Darexaban maleate is significantly reduced by the influence of fatty acid-free bovine serum albumin in both HLM and UGT1A9[1].

Molecular Weight

590.62

Formula

C31H34N4O8
CAS No.
SMILES

OC(/C=C\C(O)=O)=O.O=C(C1=CC=C(N2CCCN(CC2)C)C=C1)NC3=C(C=CC=C3O)NC(C4=CC=C(C=C4)OC)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Darexaban maleate Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Darexaban365462-24-4YM150YM 150YM-150Endogenous MetaboliteInhibitorinhibitorinhibit

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