dAURK-4

Cat. No.: HY-137344: FAQs
Data Sheet Handling Instructions

Molarity Calculator

dAURK-4, an Alisertib (HY-10971) derivative, is a potent and selective AURKA (Aurora A) degrader. dAURK-4 has anticancer effects.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (dAURK-4 hydrochloride) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

dAURK-4 Chemical Structure

CAS No. : 2705844-81-9

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Other Forms of dAURK-4:

dAURK-4 hydrochloride Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

dAURK-4, an Alisertib (HY-10971) derivative, is a potent and selective AURKA (Aurora A) degrader. dAURK-4 has anticancer effects^[1].

IC₅₀ & Target^[1]

Aurora A

In Vitro

dAURK-4 (125-1000 nM; 4-24 hours) shows degradation of AURKA in a dose-depended manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	MM.1S cells
Concentration:	125 nM, 250 nM, 500 nM, 1000 nM
Incubation Time:	4 hours or 24 hours
Result:	Inhibited the protein level of AURKA (Aurora A).

Molecular Weight

1035.47

Formula

C₅₂H₅₂ClFN₈O₁₂

CAS No.

2705844-81-9

SMILES

O=C(N(C1C(NC(CC1)=O)=O)C2=O)C3=C2C=CC=C3OCC(NCCCOCCOCCOCCCNC(C4=CC=C(NC5=NC=C6C(C(C=CC(Cl)=C7)=C7C(C8=C(F)C=CC=C8OC)=NC6)=N5)C=C4OC)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Katherine A Donovan, et al. Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development. Cell. 2020 Dec 10;183(6):1714-1731.e10. [Content Brief]

dAURK-4 Related Classifications

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

dAURK-42705844-81-9dAURK4dAURK 4PROTACsAurora KinaseAURKA degraderanticancer effectInhibitorinhibitorinhibit

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