DB-959 (Synonyms: PPARδ/γ agonist 1)

Cat. No.: HY-124244: FAQs
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DB-959 (PPARδ/γ agonist 1) is a potent PPAR agonist targeting PPARδ/γ. DB-959 improves spatial learning and memory in mice induced by Streptozotocin (HY-13753) and has the potential to improve Alzheimer's disease (AD)..

For research use only. We do not sell to patients.

DB-959 Chemical Structure

CAS No. : 1257641-15-8

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Other Forms of DB-959:

PPARδ/γ agonist 1 sodium Get quote

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PPARα PPARβ/δ PPARγ PPAR PPARδ

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Description

In Vivo

PPARδ/γ agonist 1 (1 mg/kg; i.g.; daily, for 16 days; STZ-mediated Long Evans rats) restores STZ-mediated impairments of motor function^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	STZ-mediated Long Evans rats^[1]
Dosage:	1 mg/kg
Administration:	Oral gavage; daily, for 16 days
Result:	Improved performance in the STZ-mediated rats and had neuroprotective for both granule and Purkinje cells.

Molecular Weight

421.49

Formula

C₂₅H₂₇NO₅

CAS No.

1257641-15-8

SMILES

O=C(O)C[C@@H]1CCC2=C1C=CC(OCCC3=C(CC)OC(C4=CC=C(OC)C=C4)=N3)=C2

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Tong M, et, al. T3D-959: A Multi-Faceted Disease Remedial Drug Candidate for the Treatment of Alzheimer's Disease. J Alzheimers Dis. 2016;51(1):123-38. [Content Brief]

DB-959 Related Classifications

Neurological Disease

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DB-9591257641-15-8PPARδ/γ agonist 1DB959DB 959PPARPeroxisome proliferator-activated receptorsneuroprotectivegranule cellsPurkinje cellsAlzheimer’s diseaseInhibitorinhibitorinhibit

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