2. PI3K/Akt/mTOR
  3. Akt mTOR
  4. Dehydrovomifoliol

Dehydrovomifoliol is a AKT/mTOR dual inhibitor. Dehydrovomifoliol reduces lipid accumulation and lipogenesis by inhibiting the AKT/mTOR signaling pathway. Dehydrovomifoliol is used in nonalcoholic fatty liver disease research (NAFLD) .

For research use only. We do not sell to patients.

Dehydrovomifoliol Chemical Structure

Dehydrovomifoliol Chemical Structure

CAS No. : 39763-33-2

Size Price Stock Quantity
1 mg USD 300 Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
5 mg USD 750 Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
10 mg   Get quote  
50 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Dehydrovomifoliol:

Dehydrovomifoliol Related Antibodies

Top Publications Citing Use of Products

View All Akt Isoform Specific Products:

View All Isoforms
Akt Akt1 Akt2 Akt3

View All mTOR Isoform Specific Products:

View All Isoforms
mTOR mTORC1 mTORC2

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Dehydrovomifoliol is a AKT/mTOR dual inhibitor. Dehydrovomifoliol reduces lipid accumulation and lipogenesis by inhibiting the AKT/mTOR signaling pathway. Dehydrovomifoliol is used in nonalcoholic fatty liver disease research (NAFLD) .

Cellular Effect
Cell Line Type Value Description References
A549 IC50
> 64.4 μM
Compound: 12
Cytostatic activity against human A549 cells after 48 cells by MTT assay
Cytostatic activity against human A549 cells after 48 cells by MTT assay
[PMID: 21561060]
C8166 CC50
> 450.5 μM
Compound: 12
Cytotoxicity against human C8166 cells after 3 days by MTT assay
Cytotoxicity against human C8166 cells after 3 days by MTT assay
[PMID: 21561060]
C8166 EC50
> 450.5 μM
Compound: 12
Antiviral activity against Human immunodeficiency virus 1 3B infected in human C8166 cells assessed as numbers of syncytia after 3 days by MTT assay
Antiviral activity against Human immunodeficiency virus 1 3B infected in human C8166 cells assessed as numbers of syncytia after 3 days by MTT assay
[PMID: 21561060]
HL-60 IC50
> 64.4 μM
Compound: 12
Cytostatic activity against human HL60 cells after 48 cells by MTT assay
Cytostatic activity against human HL60 cells after 48 cells by MTT assay
[PMID: 21561060]
HT-29 IC50
> 10 μM
Compound: S7
Inhibition of mitochondrial membrane potential in human HT-29 cells after 3 hrs by JC-1 staining based fluorescence assay
Inhibition of mitochondrial membrane potential in human HT-29 cells after 3 hrs by JC-1 staining based fluorescence assay
[PMID: 30057155]
HT-29 IC50
> 10 μM
Compound: S7
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay
[PMID: 30057155]
MCF7 IC50
> 64.4 μM
Compound: 12
Cytostatic activity against human MCF7 cells after 48 cells by MTT assay
Cytostatic activity against human MCF7 cells after 48 cells by MTT assay
[PMID: 21561060]
MDA-MB-435 IC50
> 10 μM
Compound: S7
Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay
Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay
[PMID: 30057155]
OVCAR-3 IC50
> 10 μM
Compound: S7
Cytotoxicity against human OVCAR3 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay
Cytotoxicity against human OVCAR3 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay
[PMID: 30057155]
RAW264.7 IC50
> 50 μM
Compound: 10
Inhibition of LPS-induced IL-1beta production in mouse RAW264.7 cells after 24 hrs by ELISA
Inhibition of LPS-induced IL-1beta production in mouse RAW264.7 cells after 24 hrs by ELISA
[PMID: 24963714]
RAW264.7 IC50
38.5 μM
Compound: 10
Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess reagent based assay
Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess reagent based assay
[PMID: 24963714]
SMMC-7721 IC50
> 64.4 μM
Compound: 12
Cytostatic activity against human SMMC7721 cells after 48 cells by MTT assay
Cytostatic activity against human SMMC7721 cells after 48 cells by MTT assay
[PMID: 21561060]
SW480 IC50
> 64.4 μM
Compound: 12
Cytostatic activity against human SW480 cells after 48 cells by MTT assay
Cytostatic activity against human SW480 cells after 48 cells by MTT assay
[PMID: 21561060]
Molecular Weight

222.28

Formula

C13H18O3
CAS No.
SMILES

CC(/C=C/[C@](C(C)(C1)C)(C(C)=CC1=O)O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Dehydrovomifoliol Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dehydrovomifoliol39763-33-2AktmTORPKBProtein kinase BMammalian target of RapamycinNAFLDInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Dehydrovomifoliol
Cat. No.:
HY-137996
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (0 KB) Français - FR (0 KB) Deutsch - DE (0 KB) Norwegian - NO (0 KB) Español - ES (0 KB) Swedish - SV (0 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.