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Deoxyharringtonine is an alkaloid isolated from Cephalotaxus genus with significant anti-leukemic activity.

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Deoxyharringtonine Chemical Structure

Deoxyharringtonine Chemical Structure

CAS No. : 36804-95-2

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Deoxyharringtonine Related Antibodies

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Description

Deoxyharringtonine is an alkaloid isolated from Cephalotaxus genus with significant anti-leukemic activity[1].

Cellular Effect
Cell Line Type Value Description References
HL-60 IC50
0.02 μM
Compound: Deoxyharringtonine
Cytotoxicity against human HL60 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
Cytotoxicity against human HL60 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
10.1039/C0MD00241K
In Vitro

Deoxyharringtonine acts on P388 leukemia cells with the IC50 value of 7.5 ng/mL. In addition, it has strong cytotoxic activity against hematopoietic cell lines such as HL-60, HL-60/RV+, JURKAT, ALL3, NCEB1, JEKO, MOLT-3, etc[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Deoxyharringtonine Related Antibodies
Molecular Weight

515.60

Formula

C28H37NO8
CAS No.
SMILES

COC1=C[C@]23N(CCC3)CCC4=CC5=C(OCO5)C=C4[C@]2([H])[C@@H]1OC([C@@](CC(OC)=O)(O)CCC(C)C)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Deoxyharringtonine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Deoxyharringtonine36804-95-2OthersCephalotaxus genusanti-leukemictumorInhibitorinhibitorinhibit

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