2. Metabolic Enzyme/Protease
  3. Thrombin
  4. Dermatan sulphate sodium

Dermatan sulphate sodium is an oral active glycosaminoglycan and thrombin inactivator with antithrombotic activity. It selectively catalyzes the heparin cofactor II-mediated inactivation of thrombin without interacting with antithrombin III. Dermatan sulphate sodium promotes stem cell differentiation, exhibits high bioavailability, and alleviates pulmonary fibrosis injury induced by Bleomycin (HY-108345). Dermatan sulphate sodium can be used in research related to cardiovascular diseases, inflammation, and stem cell differentiation.

For research use only. We do not sell to patients.

Dermatan sulphate sodium Chemical Structure

Dermatan sulphate sodium Chemical Structure

CAS No. : 54328-33-5

Size Price Stock Quantity
5 mg In-stock
10 mg   Get quote  
50 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Dermatan sulphate sodium Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Dermatan sulphate sodium is an oral active glycosaminoglycan and thrombin inactivator with antithrombotic activity. It selectively catalyzes the heparin cofactor II-mediated inactivation of thrombin without interacting with antithrombin III. Dermatan sulphate sodium promotes stem cell differentiation, exhibits high bioavailability, and alleviates pulmonary fibrosis injury induced by Bleomycin (HY-108345). Dermatan sulphate sodium can be used in research related to cardiovascular diseases, inflammation, and stem cell differentiation[1][2][3].

In Vitro

Dermatan sulphate (10 μg/mL, 7 days) sodium promoted neuronal differentiation and migration, but did not affect neurite outgrowth in hNSCs[3].
Dermatan sulphate (100 μg/mL, 12 days) sodium promoted neuronal differentiation and enhanced neurite outgrowth in mESCs[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dermatan sulphate sodium Related Antibodies

Real Time qPCR[3]

Cell Line: Human neural stem cells (hNSCs, from 14-week human fetal cerebral cortex)
Concentration: 10 μg/mL
Incubation Time: 7 days
Result: Significantly increased expression of neuronal markers (DCX, β-III-Tubulin).

Western Blot Analysis[3]

Cell Line: R1 mouse embryonic stem cells (mESCs, mouse, undifferentiated)
Concentration: 100 μg/mL
Incubation Time: 12 days
Result: Significantly enhanced p-Erk1/2 expression.
In Vivo

Dermatan sulphate (5.3 mg/kg, p.o., once daily for 28 days) sodium attenuates lung inflammation and fibrosis, and enhanced fibrinolysis in a Bleomycin (HY-108345)-induced pulmonary fibrosis model in C57 mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Bleomycin (HY-108345)-induced pulmonary fibrosis model in C57 mice[2]
Dosage: 5.3 mg/kg
Administration: Oral gavage (p.o.), once daily for 28 days
Result: Significantly reduced lung index, alleviated pulmonary edema, inflammatory infiltration, alveolar damage and collagen deposition;
Reduced lung hydroxyproline and plasma fibrinogen levels;
Increased plasma tPA levels.
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N/A
Structure Classification
Initial Source

mammals and bacteria
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

SDS (252 KB)

COA (254 KB)

Handling Instructions (2659 KB)
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Dermatan sulphate sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dermatan sulphate54328-33-5ThrombinGlycosaminoglycansthrombinpulmonary fibrosis injuryinflammatory cell infiltrationInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Dermatan sulphate sodium
Cat. No.:
HY-N8278
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (252 KB) Français - FR (252 KB) Deutsch - DE (252 KB) Norwegian - NO (252 KB) Español - ES (252 KB) Swedish - SV (252 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.