Diltiazem-d₃ hydrochloride

Name: Diltiazem-d 3 hydrochloride
Brand: MedChemExpress
SKU: HY-14656S
Rating: 4.5 (1 reviews)

Cat. No.: HY-14656S Purity: 98.46%: FAQs
Data Sheet SDS COA Handling Instructions

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Diltiazem-d₃ (hydrochloride) is the deuterium labeled Diltiazem hydrochloride. Diltiazem hydrochloride is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist)[1][2].

For research use only. We do not sell to patients.

Diltiazem-d<sub>3</sub> hydrochloride Chemical Structure

Diltiazem-d₃ hydrochloride Chemical Structure

CAS No. : 1217623-80-7

Size	Price	Stock	Quantity
1 mg	USD 296	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 740	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1250	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Diltiazem-d₃ hydrochloride:

Diltiazem hydrochloride In-stock
Diltiazem-d₅ hydrochloride Get quote

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•Related Small Molecules:

•Related Proteins:

View All Calcium Channel Isoform Specific Products:

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

Biological Activity
Purity & Documentation
References
Customer Review

Description

Diltiazem-d₃ (hydrochloride) is the deuterium labeled Diltiazem hydrochloride. Diltiazem hydrochloride is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist)[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

454.00

Formula

C₂₂H₂₄D₃ClN₂O₄S

CAS No.

1217623-80-7

Unlabeled CAS

42399-41-7

Appearance

Solid

Color

White to off-white

SMILES

CC(O[C@@H]1[C@@](C2=CC=C(C=C2)OC)([H])SC3=CC=CC=C3N(C1=O)CCN(C)C([2H])([2H])[2H])=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 33.33 mg/mL (73.41 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2026 mL	11.0132 mL	22.0264 mL
5 mM	0.4405 mL	2.2026 mL	4.4053 mL
10 mM	0.2203 mL	1.1013 mL	2.2026 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.46%

Select Batch:

Data Sheet (277 KB) SDS (252 KB)

COA (256 KB) HNMR (453 KB) RP-HPLC (365 KB) MS (1512 KB) Elemental Analysis Report (114 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Kraus RL, et al. Molecular mechanism of diltiazem interaction with L-type Ca2+ channels. J Biol Chem. 1998 Oct 16;273(42):27205-12. [Content Brief]

[3]. van Breemen C, et al. The mechanism of inhibitory action of diltiazem on vascular smooth muscle contractility. J Pharmacol Exp Ther. 1981 Aug;218(2):459-63. [Content Brief]

[4]. Chiesi M, et al. Stereospecific action of diltiazem on the mitochondrial Na-Ca exchange system and on sarcolemmal Ca-channels. Biochem Pharmacol. 1987 Sep 1;36(17):2735-40. [Content Brief]

[5]. Freitas F, et al. Cardiac microvascular rarefaction in hyperthyroid rats is reversed by losartan, diltiazem, and propranolol. Fundam Clin Pharmacol. 2015 Feb;29(1):31-40. [Content Brief]

[6]. Sato M, et al. Hypotensive effects of diltiazem hydrochloride in the normotensive, spontaneously hypertensive and renal hypertensive rats (author's transl). Nihon Yakurigaku Zasshi. 1979 Mar;75(2):99-106. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / H₂O	1 mM	2.2026 mL	11.0132 mL	22.0264 mL	55.0661 mL
	5 mM	0.4405 mL	2.2026 mL	4.4053 mL	11.0132 mL
	10 mM	0.2203 mL	1.1013 mL	2.2026 mL	5.5066 mL
	15 mM	0.1468 mL	0.7342 mL	1.4684 mL	3.6711 mL
	20 mM	0.1101 mL	0.5507 mL	1.1013 mL	2.7533 mL
	25 mM	0.0881 mL	0.4405 mL	0.8811 mL	2.2026 mL
	30 mM	0.0734 mL	0.3671 mL	0.7342 mL	1.8355 mL
	40 mM	0.0551 mL	0.2753 mL	0.5507 mL	1.3767 mL
	50 mM	0.0441 mL	0.2203 mL	0.4405 mL	1.1013 mL
	60 mM	0.0367 mL	0.1836 mL	0.3671 mL	0.9178 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.