2. Metabolic Enzyme/Protease
  3. Carbonic Anhydrase
  4. Disulfamide

Disulfamide, an orally active diuretic, is a carbonic anhydrase inhibitor with the IC50 value of 0.07 μM. Disulfamide leads to diuresis by inhibiting carbonic anhydrase and preventing the reabsorption of sodium and bicarbonate in the proximal tubule.

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Disulfamide Chemical Structure

Disulfamide Chemical Structure

CAS No. : 671-88-5

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Disulfamide Related Antibodies

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Description

Disulfamide, an orally active diuretic, is a carbonic anhydrase inhibitor with the IC50 value of 0.07 μM. Disulfamide leads to diuresis by inhibiting carbonic anhydrase and preventing the reabsorption of sodium and bicarbonate in the proximal tubule[1].

IC50 & Target

IC50: 0.07 μM (carbonic anhydrase)[1]
In Vivo

Disulfamide (intraperitoneal injection, 200 mg/kg, once) has potential blood glucose raising properties in male Wistar rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats weighing between 200-300 g[2]
Dosage: 200 mg/kg
Administration: Intraperitoneal injection; once
Result: Resulted in elevated blood sugar levels from an initial blood glucose concentration of 143.1 mg/100 mL to a one hour later final concentration of 194.6 mg/100 mL, an increase of 36%.
Molecular Weight

284.74

Formula

C7H9ClN2O4S2
CAS No.
SMILES

O=S(C1=C(C)C=C(Cl)C(S(=O)(N)=O)=C1)(N)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Disulfamide Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Disulfamide671-88-5Carbonic AnhydraseCarbonate dehydratasecarbonic anhydrasediuretic,Inhibitorinhibitorinhibit

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