2. Anti-infection NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Fungal Reactive Oxygen Species
  4. Dithianon

Dithianon is a broad-spectrum anthraquinone fungicide with good adherence to the surface of leaves and fruits. Dithianon is used to control several several fungal of some fruits and vegetables, as anthracnose (Colletotrichum sp., Elsinoe ampelina), mildew (Plasmopara viticola), phomopsis (Phomopsis viticola), among others.

For research use only. We do not sell to patients.

Dithianon Chemical Structure

Dithianon Chemical Structure

CAS No. : 3347-22-6

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Based on 1 publication(s) in Google Scholar

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Dithianon Related Antibodies

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Description

Dithianon is a broad-spectrum anthraquinone fungicide with good adherence to the surface of leaves and fruits. Dithianon is used to control several several fungal of some fruits and vegetables, as anthracnose (Colletotrichum sp., Elsinoe ampelina), mildew (Plasmopara viticola), phomopsis (Phomopsis viticola), among others[1][2].

IC50 & Target

Reactive oxygen species (ROS)[1]
Colletotrichum sp.; Elsinoe ampelina; Plasmopara viticola; Phomopsis viticola[1]
In Vitro

When exponentially aerobic growing cells of S. cerevisiae are submitted to acute Dithianon treatment they loss cell wall and membrane integrity, dying by necrosis, and this behavior is associated to a depletion of reduced proteic and non-proteic thiol groups. An important increase of cellular reactive oxygen species (ROS) associated to mitochondrial membrane potential modifications on Dithianon treated cells are also detected[1].
In filamentous fungus, Dithianon inhibits mycelial growth and conidial germination. Studies on Ehrlich ascites carcinoma and yeast cells showed that Dithianon inhibits respiration and fermentation affecting several thiol enzymes of the glycolytic pathway as hexokinase, phosphofructokinase, and glyceraldeyde-3-phosphate dehydrogenase[1].
Dithianon has in vitro cytotoxic effect and affect cell transforming activity of BLAB/c 3 T3 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dithianon Related Antibodies
In Vivo

The activity of testosterone hydroxylase of liver microsomes derived from male mice is increased when they are treated with acute doses of Dithianon, while in females an inactivating effect is observed[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

296.32

Formula

C14H4N2O2S2
CAS No.
SMILES

N#CC1=C(C#N)SC(C(C2=C3C=CC=C2)=O)=C(C3=O)S1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Dithianon Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dithianon3347-22-6FungalReactive Oxygen SpeciesBroad-spectrumanthraquinonepesticidenecrosisROSadherencefungaldiseasesmitochondrialglycolyticInhibitorinhibitorinhibit

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