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  4. DL-threo-PPMP

DL-threo-PPMP is an inhibitor of sphingosine synthetase in Plasmodium falciparum. DL-threo-PPMP inhibits the activity of sphingosine synthetase by mimicking the substrate sphingosine. This inhibition leads to a rapid decrease in the activity of sensitive sphingosine synthetase, selectively destroying the interconnected tubular network of TVMs in the host cell cytoplasm, and this inhibition also blocks the proliferation of Plasmodium falciparum. DL-threo-PPMP can be used for the study of Plasmodium biology and the search for new antimalarial strategies.

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DL-threo-PPMP Chemical Structure

DL-threo-PPMP Chemical Structure

CAS No. : 149022-18-4

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Other Forms of DL-threo-PPMP:

DL-threo-PPMP Related Antibodies

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Description

DL-threo-PPMP is an inhibitor of sphingosine synthetase in Plasmodium falciparum. DL-threo-PPMP inhibits the activity of sphingosine synthetase by mimicking the substrate sphingosine. This inhibition leads to a rapid decrease in the activity of sensitive sphingosine synthetase, selectively destroying the interconnected tubular network of TVMs in the host cell cytoplasm, and this inhibition also blocks the proliferation of Plasmodium falciparum. DL-threo-PPMP can be used for the study of Plasmodium biology and the search for new antimalarial strategies[1].

Molecular Weight

474.72

Formula

C29H50N2O3
CAS No.
SMILES

O=C(N[C@@H]([C@@H](C1=CC=CC=C1)O)CN2CCOCC2)CCCCCCCCCCCCCCC
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DL-threo-PPMP Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DL-threo-PPMP149022-18-4ParasiteMalariaPlasmodiumSphingosine synthetaseTVMSSSInhibitorinhibitorinhibit

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