2. PROTAC Epigenetics Apoptosis
  3. PROTACs Epigenetic Reader Domain Apoptosis
  4. DP-15

DP-15 is the degrader for GSPT1 and BRD4 with DC50 of 5.25 nM and 0.48 nM. DP-15 exhibits anti-proliferative activity of AML cells and NHL cells with an IC50 of nanomolar levels, arrests the cell cycle at G1 phase, and induces apoptosis in MOLM13. DP-15 exhibits anti-leukemia activity in MOLM-13 xenograft mouse models. (Pink: ligand for target protein (HY-78695); Black: linker (HY-W262798); Blue: ligand for E3 ligase CRBN (HY-23095))

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DP-15 Chemical Structure

DP-15 Chemical Structure

CAS No. : 3033837-71-4

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DP-15 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

DP-15 is the degrader for GSPT1 and BRD4 with DC50 of 5.25 nM and 0.48 nM. DP-15 exhibits anti-proliferative activity of AML cells and NHL cells with an IC50 of nanomolar levels, arrests the cell cycle at G1 phase, and induces apoptosis in MOLM13. DP-15 exhibits anti-leukemia activity in MOLM-13 xenograft mouse models[1]. (Pink: ligand for target protein (HY-78695); Black: linker (HY-W262798); Blue: ligand for E3 ligase CRBN (HY-23095))

Molecular Weight

822.37

Formula

C42H44ClN9O5S
CAS No.
SMILES

CC1=C(C)SC2=C1C(C3=CC=C(C=C3)Cl)=N[C@@H](CC(N4CCN(CC4)CC5CCN(C6=CC=C(C(N(C7C(NC(CC7)=O)=O)C8=O)=O)C8=C6)CC5)=O)C9=NN=C(C)N29
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DP-15 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DP-153033837-71-4DP15DP 15PROTACsEpigenetic Reader DomainApoptosisMOLM13AMLNHLOCI-AML3NB4THP-1HL-60,SU-DHL-1RajiKarpas299DaudiInhibitorinhibitorinhibit

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