2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. DPDPE

DPDPE, an opioid peptide, is a selective δ-opioid receptor?(DOR) agonist?with anticonvulsant effects.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

DPDPE Chemical Structure

DPDPE Chemical Structure

CAS No. : 88373-73-3

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1 mg USD 100 In-stock
5 mg USD 280 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of DPDPE:

DPDPE Related Antibodies

Top Publications Citing Use of Products

View All Opioid Receptor Isoform Specific Products:

View All Isoforms
μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

DPDPE, an opioid peptide, is a selective δ-opioid receptor?(DOR) agonist?with anticonvulsant effects[1].

IC50 & Target

δ Opioid Receptor/DOR

 

Cellular Effect
Cell Line Type Value Description References
CHO EC50
0.12 nM
Compound: DPDPE
Agonist activity at human DOR expressed in CHO cell membranes after 60 mins by [35S]GTP-gamma-S binding assay
Agonist activity at human DOR expressed in CHO cell membranes after 60 mins by [35S]GTP-gamma-S binding assay
[PMID: 27096047]
CHO IC50
1.3 nM
Compound: DPDPE
Displacement of [3H]DADLE from human recombinant delta opioid receptor expressed in CHO cells measured after 120 mins by scintillation counting method
Displacement of [3H]DADLE from human recombinant delta opioid receptor expressed in CHO cells measured after 120 mins by scintillation counting method
[PMID: 27876250]
CHO EC50
10 nM
Compound: DPDPE
Agonist activity at mouse delta opioid receptor-1 expressed in CHO cell membranes assessed as [35S]GTPgammaS binding incubated for 60 mins by scintillation spectroscopic analysis
Agonist activity at mouse delta opioid receptor-1 expressed in CHO cell membranes assessed as [35S]GTPgammaS binding incubated for 60 mins by scintillation spectroscopic analysis
[PMID: 27556704]
CHO EC50
13.2 nM
Compound: DPDPE
Agonist activity at human delta opioid receptor over-expressed in CHO cell membrane after 1 hr by [35S]GTPgammaS binding assay
Agonist activity at human delta opioid receptor over-expressed in CHO cell membrane after 1 hr by [35S]GTPgammaS binding assay
[PMID: 26525865]
CHO EC50
8.01 nM
Compound: DPDPE
Inverse agonist activity at human DOR expressed in CHO cell membranes by [35S]GTPgammaS binding assay
Inverse agonist activity at human DOR expressed in CHO cell membranes by [35S]GTPgammaS binding assay
[PMID: 26048798]
HEK293 IC50
0.0003 μM
Compound: DPDPE
Agonist activity at human DOR expressed in HEK293 cells assessed as inhibition of forskolin-induced adenylyl cyclase-mediated cAMP accumulation after 30 mins by HTRF assay
Agonist activity at human DOR expressed in HEK293 cells assessed as inhibition of forskolin-induced adenylyl cyclase-mediated cAMP accumulation after 30 mins by HTRF assay
[PMID: 27776274]
HEK293 IC50
1.6 nM
Compound: DPDPE
Agonist activity at human MOR expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation by EIA method
Agonist activity at human MOR expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation by EIA method
[PMID: 27607020]
HEK293 IC50
1.6 nM
Compound: DPDPE
Agonist activity at human DOR expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation by EIA method
Agonist activity at human DOR expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation by EIA method
[PMID: 27607020]
In Vivo

DPDPE (70 or 140 nM; i.c.v.; once) shows anticonvulsant effects in rats[1].
DPDPE (0.78–25 μg/mouse; i.c.v.; once) enhances bicuculline-induced convulsions in mouse[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (225-275 g)[1]
Dosage: 70 or 140 nM followed by a 2 μl saline flush
Administration: Intracerebroventricular injection
Result: Resulted in a significant, dose-dependent increase in the convulsive threshold to flurothyl.
Animal Model: Male ddY mice weighing 20–30 g, pretreated with 1.5 mg/kg bicuculline (subcutaneous injection)[2].
Dosage: 0.78–25 μg/mouse, once
Administration: Intracerebroventricular injection
Result: Caused a dose-dependent increase in the proportion of mice exhibiting convulsions.
Molecular Weight

645.79

Formula

C30H39N5O7S2
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Tyr-{Pen}-Gly-Phe-{Pen} (Disulfide bridge:Pen2-Pen5)
Sequence Shortening

Y{Pen}GF{Pen} (Disulfide bridge:Pen2-Pen5)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 10 mg/mL (15.48 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5485 mL 7.7425 mL 15.4849 mL
5 mM 0.3097 mL 1.5485 mL 3.0970 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.5485 mL 7.7425 mL 15.4849 mL 38.7123 mL
5 mM 0.3097 mL 1.5485 mL 3.0970 mL 7.7425 mL
10 mM 0.1548 mL 0.7742 mL 1.5485 mL 3.8712 mL
15 mM 0.1032 mL 0.5162 mL 1.0323 mL 2.5808 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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DPDPE Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DPDPE88373-73-3Opioid Receptoranticonvulsant effectsInhibitorinhibitorinhibit

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