2. Metabolic Enzyme/Protease
  3. Dipeptidyl Peptidase
  4. DPP8/9-IN-1

DPP8/9-IN-1 (Compound 16) is a selective covalent inhibitor of dipeptidyl peptidases 8 and 9 (DPP8/9) with IC50 values of 14 and 298 nM, respectively. DPP8/9-IN-1 binds irreversibly to the active site serine (S730 in DPP9) via a phosphonate warhead and blocks substrate binding to inhibit DPP8/9-mediated protein processing. DPP8/9-IN-1 is promising for research of cancers and inflammatory diseases.

For research use only. We do not sell to patients.

DPP8/9-IN-1 Chemical Structure

DPP8/9-IN-1 Chemical Structure

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DPP8/9-IN-1 Related Antibodies

Top Publications Citing Use of Products

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DPP-1 DPP-2 DPP-4 DPP-8 DPP-9

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Description

DPP8/9-IN-1 (Compound 16) is a selective covalent inhibitor of dipeptidyl peptidases 8 and 9 (DPP8/9) with IC50 values of 14 and 298 nM, respectively. DPP8/9-IN-1 binds irreversibly to the active site serine (S730 in DPP9) via a phosphonate warhead and blocks substrate binding to inhibit DPP8/9-mediated protein processing. DPP8/9-IN-1 is promising for research of cancers and inflammatory diseases[1].

IC50 & Target

DPP-8

14 nM (IC50)

DPP-9

298 nM (IC50)

Molecular Weight

412.53

Formula

C20H33N2O3PS
SMILES

N[C@@H]1C(N(P(OCC)(CCSC(C=C2)=CC=C2CCCCC)=O)CCC1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DPP8/9-IN-1 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DPP8/9-IN-1Dipeptidyl PeptidaseDPPDPP8/9cancers and inflammatory diseasesInhibitorinhibitorinhibit

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