2. Anti-infection Metabolic Enzyme/Protease
  3. Parasite Dihydroorotate Dehydrogenase
  4. DSM1465

DSM1465 (Compound 82) is a potent, selective inhibitor of P. falciparum dihydroorotate dehydrogenase (PfDHODH) with an IC50 value of 15 nM, inhibits P. falciparum 3D7 (Pf3D7) parasites with an EC50 value of 1.4 nM. DSM1465 shows potent in vivo activity in the humanized P. falciparum mouse model.

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DSM1465 Chemical Structure

DSM1465 Chemical Structure

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DSM1465 Related Antibodies

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Description

DSM1465 (Compound 82) is a potent, selective inhibitor of P. falciparum dihydroorotate dehydrogenase (PfDHODH) with an IC50 value of 15 nM, inhibits P. falciparum 3D7 (Pf3D7) parasites with an EC50 value of 1.4 nM. DSM1465 shows potent in vivo activity in the humanized P. falciparum mouse model[1].

Molecular Weight

467.75

Formula

C17H12ClF6N5O2
SMILES

O=C1C2=NN(C)C([C@](O)(C3=CC(Cl)=C(C(F)(F)F)N=C3)C(F)(F)F)=C2N=CN1C4CC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DSM1465 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DSM1465DSM 1465DSM-1465ParasiteDihydroorotate DehydrogenaseDHODHPfDHODHparasitemouseInhibitorinhibitorinhibit

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