2. JAK/STAT Signaling PI3K/Akt/mTOR Apoptosis Autophagy Protein Tyrosine Kinase/RTK MAPK/ERK Pathway
  3. EGFR Akt Autophagy p38 MAPK c-Met/HGFR Apoptosis
  4. (E/Z)-Afatinib (Standard)

(E/Z)-Afatinib (Standard) 

Cat. No.: HY-10261BR Purity: ≥98%
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(E/Z)-Afatinib (Standard) is the analytical standard of (E/Z)-Afatinib. This product is intended for research and analytical applications. (E/Z)-Afatinib ((E/Z)-BIBW 2992) is the mixture of (E)-Afatinib and (Z)-Afatinib. Afatinib (HY-10261) is an irreversible inhibitor of EGFR, by irreversibly binding to their ATP binding site to block activation of EGFR, HER2, HER4, and EGFRvIII. Afatinib used in co-administration with Temozolomide (HY-17364), potently targeting to EGFRvIII-cMet signaling in glioblastoma cells.

For research use only. We do not sell to patients.

(E/Z)-Afatinib (Standard) Chemical Structure

(E/Z)-Afatinib (Standard) Chemical Structure

CAS No. : 439081-18-2

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Description

(E/Z)-Afatinib (Standard) is the analytical standard of (E/Z)-Afatinib. This product is intended for research and analytical applications. (E/Z)-Afatinib ((E/Z)-BIBW 2992) is the mixture of (E)-Afatinib and (Z)-Afatinib. Afatinib (HY-10261) is an irreversible inhibitor of EGFR, by irreversibly binding to their ATP binding site to block activation of EGFR, HER2, HER4, and EGFRvIII. Afatinib used in co-administration with Temozolomide (HY-17364), potently targeting to EGFRvIII-cMet signaling in glioblastoma cells.

Molecular Weight

485.94

Formula

C24H25ClFN5O3
CAS No.
SMILES

O=C(/C=C/CN(C)C)NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1O[C@@H]4COCC4
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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(E/Z)-Afatinib (Standard) Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E/Z)-Afatinib (Standard)439081-18-2EGFRAktAutophagyp38 MAPKc-Met/HGFRApoptosisEpidermal growth factor receptorErbB-1HER1PKBProtein kinase Bbiochemical reagentbiological materialorganic compoundlife scienceInhibitorinhibitorinhibit

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