(E/Z)-Dacinostat (Synonyms: (E/Z)-NVP-LAQ824; (E/Z)-LAQ824)

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(E/Z)-Dacinostat ((E/Z)-NVP-LAQ824) is a histone deacetylase inhibitor that has the ability to induce apoptosis and enhance the activity of fludarabine in killing leukemia cells. (E/Z)-Dacinostat can trigger the production of reactive oxygen species (ROS) and DNA damage, enhance the killing effect of fludarabine on leukemia cells, and induce apoptosis. Its mechanism is related to the regulation of DNA repair processes and intracellular signaling pathways.

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(E/Z)-Dacinostat Chemical Structure

CAS No. : 591207-53-3

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Description	(E/Z)-Dacinostat ((E/Z)-NVP-LAQ824) is a histone deacetylase inhibitor that has the ability to induce apoptosis and enhance the activity of fludarabine in killing leukemia cells. (E/Z)-Dacinostat can trigger the production of reactive oxygen species (ROS) and DNA damage, enhance the killing effect of fludarabine on leukemia cells, and induce apoptosis. Its mechanism is related to the regulation of DNA repair processes and intracellular signaling pathways.
Molecular Weight	379.45
Formula	C₂₂H₂₅N₃O₃
CAS No.	591207-53-3
SMILES	O=C(/C=C/C1=CC=C(C=C1)CN(CCC2=CC3=C(C=CC=C3)N2)CCO)NO
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (264 KB) Handling Instructions (2659 KB)
References	[1]. Role of histone deacetylase inhibitor-induced reactive oxygen species and DNA damage in LAQ-824/fludarabine antileukemic interactions [Content Brief]

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E/Z)-Dacinostat591207-53-3(E/Z)-NVP-LAQ824 (E/Z)-LAQ824OthersInhibitorinhibitorinhibit

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(E/Z)-Dacinostat (Synonyms: (E/Z)-NVP-LAQ824; (E/Z)-LAQ824)

Other Forms of (E/Z)-Dacinostat:

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Featured Recommendations

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Biological Activity

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References

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