2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR
  3. EGFR Akt
  4. EGFR/Akt-IN-1

EGFR/Akt-IN-1 (compound 17) is a potent inhibitor of EGFR/Akt, with the IC50s of 12.89 μM and 10.88 μM in A549 cells, respectively. EGFR/Akt-IN-1 arrestes the cell cycle at the S phase.

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EGFR/Akt-IN-1 Chemical Structure

EGFR/Akt-IN-1 Chemical Structure

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EGFR/Akt-IN-1 Related Antibodies

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Description

EGFR/Akt-IN-1 (compound 17) is a potent inhibitor of EGFR/Akt, with the IC50s of 12.89 μM and 10.88 μM in A549 cells, respectively. EGFR/Akt-IN-1 arrestes the cell cycle at the S phase[1].

Molecular Weight

415.47

Formula

C22H17N5O2S
SMILES

N#CC1=CC=C(C2=CN3C(SC=C3CC(N/N=C/C4=CC=C(OC)C=C4)=O)=N2)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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EGFR/Akt-IN-1 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR/Akt-IN-1EGFRAktEpidermal growth factor receptorErbB-1HER1PKBProtein kinase BA549 cellsGSK690693erlotinibInhibitorinhibitorinhibit

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