2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK MAPK/ERK Pathway Apoptosis
  3. EGFR Raf Apoptosis
  4. EGFR/BRAFV600E-IN-1

EGFR/BRAFV600E-IN-1 (Compound 23) is a potent EGFR and BRAFV600E dual inhibitor with IC50s of 0.08 and 0.15 µM, respectively. EGFR/BRAFV600E-IN-1 induces apoptosis and cell cycle arrest in both pre-G1 and G2/M phases. EGFR/BRAFV600E-IN-1 exhibits antiproliferative activity againist A-549, MCF-7, Panc-1, HT-29 with IC50s of 1.2, 0.79, 1.3, and 1.23 µM, respectively.

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EGFR/BRAFV600E-IN-1 Chemical Structure

EGFR/BRAFV600E-IN-1 Chemical Structure

CAS No. : 2492429-45-3

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EGFR/BRAFV600E-IN-1 Related Antibodies

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Description

EGFR/BRAFV600E-IN-1 (Compound 23) is a potent EGFR and BRAFV600E dual inhibitor with IC50s of 0.08 and 0.15 µM, respectively. EGFR/BRAFV600E-IN-1 induces apoptosis and cell cycle arrest in both pre-G1 and G2/M phases. EGFR/BRAFV600E-IN-1 exhibits antiproliferative activity againist A-549, MCF-7, Panc-1, HT-29 with IC50s of 1.2, 0.79, 1.3, and 1.23 µM, respectively[1].

Molecular Weight

437.92

Formula

C24H24ClN3O3
CAS No.
SMILES

O=C1N(CCC2=CC=C(N3CCOCC3)C=C2)CC(N4C1=C(C)C5=C4C=CC(Cl)=C5)=O
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References
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EGFR/BRAFV600E-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR/BRAFV600E-IN-12492429-45-3EGFRRafApoptosisEpidermal growth factor receptorErbB-1HER1Raf kinasesAntiproliferativeBRAFV600EInhibitorinhibitorinhibit

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