EGFR/HER2/TS-IN-1

Cat. No.: HY-146238: FAQs
Data Sheet Handling Instructions

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EGFR/HER2/TS-IN-1 (Compound 4d) is an EGFR, HER2 and TS (Thymidylate synthase) inhibitor with IC₅₀ values of 0.203, 0.088 and 0.168 μM against EGFR, HER2 and TS, respectively. EGFR/HER2/TS-IN-1 induces MCF7 cell apoptosis.

For research use only. We do not sell to patients.

EGFR/HER2/TS-IN-1 Chemical Structure

CAS No. : 2444363-11-3

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

HER2

0.088 μM (IC₅₀)

Thymidylate synthase

0.168 μM (IC₅₀)

EGFR

0.203 μM (IC₅₀)

In Vitro

EGFR/HER2/TS-IN-1 (Compound 4d) shows cytotoxicity with an IC₅₀ of 0.693 μM against MCF7 cells^[1].
EGFR/HER2/TS-IN-1 (10 μg, 24 h) arrests cell cycle at G2/M phase and induces cell apoptosis in MCF7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:	MCF7
Concentration:	10 μg
Incubation Time:	24 h
Result:	Arrested cell cycle at G2/M phase.

Apoptosis Analysis^[1]

Cell Line:	MCF7
Concentration:	10 μg
Incubation Time:	24 h
Result:	Induced cell apoptosis.

Molecular Weight

501.54

Formula

C₂₄H₁₅N₅O₄S₂

CAS No.

2444363-11-3

SMILES

N#CC1=C(C2=COC3=C(C2=O)C=CC=C3)NC(SCC(NC4=NC5=C(S4)C=C(C)C=C5)=O)=NC1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Abdellatif KRA, et al. Design, synthesis, molecular docking and antiproliferative activity of some novel benzothiazole derivatives targeting EGFR/HER2 and TS. Bioorg Chem. 2020 Aug;101:103976. [Content Brief]

EGFR/HER2/TS-IN-1 Related Classifications

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR/HER2/TS-IN-12444363-11-3EGFRThymidylate SynthaseApoptosisEpidermal growth factor receptorErbB-1HER1MCF7antitumorInhibitorinhibitorinhibit

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