2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. EGFR-IN-132

EGFR-IN-132 (Compound 23) is an inhibitor for EGFR, that inhibits the EGFR wildtype, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S mutans with IC50 of 1.6, 0.025, 0.019, 0.022, and 0.029 nM. EGFR-IN-132 exhibits good pharmacokinetics characteristics with high oral exposure.

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EGFR-IN-132 Chemical Structure

EGFR-IN-132 Chemical Structure

CAS No. : 2809982-20-3

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EGFR-IN-132 Related Antibodies

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Description

EGFR-IN-132 (Compound 23) is an inhibitor for EGFR, that inhibits the EGFR wildtype, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S mutans with IC50 of 1.6, 0.025, 0.019, 0.022, and 0.029 nM. EGFR-IN-132 exhibits good pharmacokinetics characteristics with high oral exposure[1].

IC50 & Target

EGFR (WT)

1.6 nM (IC50)

Molecular Weight

501.58

Formula

C27H31N7O3
CAS No.
SMILES

C[C@H]1CN2C3=CC=C(NC4COC4)C=C3N/C2=N\C(C5=CC(C)=NC(C6=C(N(N=C6)C)OCCC1)=C5)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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EGFR-IN-132 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-1322809982-20-3EGFREpidermal growth factor receptorErbB-1HER1Inhibitorinhibitorinhibit

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